ArticleIntensive care medicine2006
Monitoring dead space during recruitment and PEEP titration in an experimental model.
Article in Intensive care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 116 citations in OpenAlex.
- Prognostic value of time-varying dead space estimates in mechanically ventilated patients with acute respiratory distress syndrome.Journal of intensive medicine · 2024Article
- Whole lung lavage decreases physiological dead space in patients with pulmonary alveolar proteinosis: two case reports.Journal of medical case reports · 2023Article
- Dead space ventilation-related indices: bedside tools to evaluate the ventilation and perfusion relationship in patients with acute respiratory distress syndrome.Critical care (London, England) · 2023Review
- A structured narrative review of clinical and experimental studies of the use of different positive end-expiratory pressure levels during thoracic surgery.The clinical respiratory journal · 2022Review
- Difference between arterial and end-tidal carbon dioxide and adverse events after non-cardiac surgery: a historical cohort study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2022Article
- Physiologic Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome.American journal of respiratory and critical care medicine · 2019Observational
- Dead space in acute respiratory distress syndrome.Annals of translational medicine · 2018Review
- Exhaled COJournal of critical care · 2018Article
- Volumetric but Not Time Capnography Detects Ventilation/Perfusion Mismatch in Injured Rabbit Lung.Frontiers in physiology · 2018Article
- Physiologic Factors Influencing the Arterial-To-End-Tidal COFrontiers in veterinary science · 2018Article
- Personalizing mechanical ventilation according to physiologic parameters to stabilize alveoli and minimize ventilator induced lung injury (VILI).Intensive care medicine experimental · 2017Review
- Application of dead space fraction to titrate optimal positive end-expiratory pressure in an ARDS swine model.Experimental and therapeutic medicine · 2017Article
- Recent Advances in Pediatric Ventilatory Assistance.F1000Research · 2017Review
- Dead space in acute respiratory distress syndrome: more than a feeling!Critical care (London, England) · 2016Article
- Capnogram slope and ventilation dead space parameters: comparison of mainstream and sidestream techniques.British journal of anaesthesia · 2016Article
- Volumetric capnography: lessons from the past and current clinical applications.Critical care (London, England) · 2016Review
- Detection of optimal PEEP for equal distribution of tidal volume by volumetric capnography and electrical impedance tomography during decreasing levels of PEEP in post cardiac-surgery patients.British journal of anaesthesia · 2016Article
- Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials.Critical care medicine · 2015Article
- Detection of 'best' positive end-expiratory pressure derived from electrical impedance tomography parameters during a decremental positive end-expiratory pressure trial.Critical care (London, England) · 2014Article
- Effect of intra-abdominal pressure on respiratory function in patients undergoing ventral hernia repair.World journal of critical care medicine · 2013Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo test the usefulness of dead space for determining open-lung PEEP, the lowest PEEP that prevents lung collapse after a lung recruitment maneuver.
designProspective animal study.
settingDepartment of Clinical Physiology, University of Uppsala, Sweden. SUBJECTS: Eight lung-lavaged pigs.
interventionsAnimals were ventilated using constant flow mode with VT of 6ml/kg, respiratory rate of 30bpm, inspiratory-to-expiratory ratio of 1:2, and FiO(2) of 1. Baseline measurements were performed at 6cmH(2)O of PEEP. PEEP was increased in steps of 6cmH(2)O from 6 to 24cmH(2)O. Recruitment maneuver was achieved within 2min at pressure levels of 60/30cmH(2)O for Peak/PEEP. PEEP was decreased from 24 to 6cmH(2)O in steps of 2cmH(2)O and then to 0cmH(2)O. Each PEEP step was maintained for 10min. MEASUREMENTS AND
resultsAlveolar dead space (VD(alv)), the ratio of alveolar dead space to alveolar tidal volume (VD(alv)/VT(alv)), and the arterial to end-tidal PCO(2) difference (Pa-ET: CO(2)) showed a good correlation with PaO(2), normally aerated areas, and non-aerated CT areas in all animals (minimum-maximum r(2)=0.83-0.99; p<0.01). Lung collapse (non-aerated tissue>5%) started at 12[Symbol: see text]cmH(2)O PEEP; hence, open-lung PEEP was established at 14cmH(2)O. The receiver operating characteristics curve demonstrated a high specificity and sensitivity of VD(alv) (0.89 and 0.90), VD(alv)/VT(alv) (0.82 and 1.00), and Pa-ET: CO(2) (0.93 and 0.95) for detecting lung collapse.
conclusionsMonitoring of dead space was useful for detecting lung collapse and for establishing open-lung PEEP after a recruitment maneuver.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.