ReviewMolecular systems biology2006
Imaging single molecules in living cells for systems biology.
Review in Molecular systems biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Understanding and manipulating extracellular behaviors of Wnt ligands.In vitro cellular & developmental biology. Animal · 2024Review
- Bacterial Vivisection: How Fluorescence-Based Imaging Techniques Shed a Light on the Inner Workings of Bacteria.Microbiology and molecular biology reviews : MMBR · 2020Review
- The significance of membrane fluidity of feeder cell-derived substrates for maintenance of iPS cell stemness.Scientific reports · 2015Article
- Guidelines for the fitting of anomalous diffusion mean square displacement graphs from single particle tracking experiments.PloS one · 2015Article
- Studying the organization of DNA repair by single-cell and single-molecule imaging.DNA repair · 2014Review
- New insights into replisome fluidity during chromosome replication.Trends in biochemical sciences · 2013Review
- High-speed atomic force microscopy combined with inverted optical microscopy for studying cellular events.Scientific reports · 2013Article
- Determination of a threshold dose to reduce or eliminate CdTe-induced toxicity in L929 cells by controlling the exposure dose.PloS one · 2013Article
- Origins of concentration dependence of waiting times for single-molecule fluorescence binding.The Journal of chemical physics · 2012Article
- Multicolour single molecule imaging on cells using a supercontinuum source.Biomedical optics express · 2012Article
- Functioning nanomachines seen in real-time in living bacteria using single-molecule and super-resolution fluorescence imaging.International journal of molecular sciences · 2011Review
- The role of physiological heterogeneity in microbial population behavior.Nature chemical biology · 2010Review
- Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules.Molecular biology of the cell · 2010Article
- A RasGTP-induced conformational change in C-RAF is essential for accurate molecular recognition.Biophysical journal · 2009Article
- Single-molecule analysis of CD9 dynamics and partitioning reveals multiple modes of interaction in the tetraspanin web.The Journal of cell biology · 2008Article
- Regulated motion of glycoproteins revealed by direct visualization of a single cargo in the endoplasmic reticulum.The Journal of cell biology · 2008Article
- Modelling reaction kinetics inside cells.Essays in biochemistry · 2008Review
- From mouse genetics to systems biology.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, I present the application of single-molecule imaging to systems biology and discuss the relevant technical issues within this context. Imaging single molecules has made it possible to visualize individual molecules at work in living cells. This continuously improving technique allows the measurement of non-invasively quantitative parameters of intracellular reactions, such as the number of molecules, reaction rate constants and diffusion coefficients with spatial distributions and temporal fluctuations. This detailed information about unitary intracellular reactions is essential for constructing quantitative models of reaction networks that provide a systems-level understanding of the mechanisms by which various cellular behaviors are emerging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.