ArticleJPEN. Journal of parenteral and enteral nutrition
Impact of caloric intake on parenteral nutrition-associated intestinal morphology and mucosal barrier function.
Article in JPEN. Journal of parenteral and enteral nutrition. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Glutamine and recombinant human growth hormone protect intestinal barrier function following portal hypertension surgery.World journal of gastroenterology · 2007Trial
- Intermittent vs. continuous: a comparative narrative review of enteral and parenteral nutrition support strategies in the perioperative setting.European journal of clinical nutrition · 2026Review
- Is an Early Resumption of a Regular Diet After Laparoscopic Roux-en-Y Gastric Bypass Safe?Obesity surgery · 2022Article
- Enteral feeding and the microbiome in critically ill children: a narrative review.Translational pediatrics · 2021Review
- Percutaneous endoscopic gastrostomy - Too often? Too late? Who are the right patients for gastrostomy?World journal of gastroenterology · 2020Review
- Review
- Magnolol and Honokiol Attenuate Apoptosis of Enterotoxigenic Escherichia Coli-Induced Intestinal Epithelium by Maintaining Secretion and Absorption Homeostasis and Protecting Mucosal Integrity.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Effects ofJournal of animal science and biotechnology · 2018Article
- Effect of minimal enteral feeding on recovery in a methotrexate-induced gastrointestinal mucositis rat model.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum.Cellular and molecular gastroenterology and hepatology · 2016Article
- TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Enhanced oral bioavailability of vancomycin in rats treated with long-term parenteral nutrition.SpringerPlus · 2015Article
- Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Intestinal epithelial cell apoptosis and loss of barrier function in the setting of altered microbiota with enteral nutrient deprivation.Frontiers in cellular and infection microbiology · 2013Review
- Glutamine prevents total parenteral nutrition-associated changes to intraepithelial lymphocyte phenotype and function: a potential mechanism for the preservation of epithelial barrier function.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2010Article
- Effects of caloric intake on intestinal mucosal morphology and immune cells in rats treated with 5-Fluorouracil.Journal of clinical biochemistry and nutrition · 2009Article
- Dissociation of E-cadherin and beta-catenin in a mouse model of total parenteral nutrition: a mechanism for the loss of epithelial cell proliferation and villus atrophy.The Journal of physiology · 2009Article
- Enteral and parenteral nutrition distinctively modulate intestinal permeability and T cell function in vitro.European journal of nutrition · 2009Article
- Early postoperative enteral nutrition is useful for recovering gastrointestinal motility and maintaining the nutritional status.Surgery today · 2009Article
- Kampo medicine "Dai-kenchu-to" prevents bacterial translocation in rats.Digestive diseases and sciences · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundParenteral nutrition (PN) is known to induce villus atrophy, epithelial cell (EC) apoptosis, and increase mucosal permeability. The study hypothesized that increasing amounts of energy delivery to mice would result in the best outcome, with the least effects on the mucosa.
methodsMice were randomized to enteral controls (saline infusion with ad libitum enteral food) or to 1 of 3 PN groups (with no enteral nutrition): full (100% of daily average energy intake for the mouse), reduced (75% of energy intake) or very low (50% of energy intake). Mice received PN for 7 days. Mucosal morphology, EC apoptosis, and bacterial translocation were assessed.
resultsVillus height decreased significantly with decreasing levels of caloric intake and was significantly lower in all PN groups compared with controls. Body weight loss was significantly greater in PN groups vs controls and was greatest in mice with the lowest caloric delivery. A consistent trend toward a higher EC apoptotic index with decreasing caloric intake was observed, and apoptosis in all PN groups exceeded controls (2-fold). All PN groups demonstrated greater bacterial translocation than controls.
conclusionsPN induces intestinal EC apoptosis and villus and crypt atrophy, even at 100% of predicted energy needs, and such changes increased with greater reduction of energy intake. This study supports a concept that lack of enteral nutrition, rather than absolute caloric levels, is responsible for many of the adverse effects of PN. The study also allows the investigators to better optimize a mouse model of PN delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.