ArticleBiological psychiatry2007
Fine-tuning of awake prefrontal cortex neurons by clozapine: comparison with haloperidol and N-desmethylclozapine.
Article in Biological psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Response to initial antipsychotic treatment in first episode psychosis is related to anterior cingulate glutamate levels: a multicentreMolecular psychiatry · 2018Trial
- Associations between glutamate and cerebral blood flow in treatment-resistant schizophrenia during clozapine treatment.Journal of psychopharmacology (Oxford, England) · 2026Article
- NeuropsychopharmARCology: Shaping Neuroplasticity through Arc/ Arg3.1 Modulation.Current neuropharmacology · 2025Review
- Effects of Ketamine on Frontoparietal Interactions in a Rule-Based Antisaccade Task in Macaque Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Differential Effects of Clozapine and Haloperidol on the 40 Hz Auditory Steady State Response-mediated Phase Resetting in the Prefrontal Cortex of the Female Sprague Dawley Rat.Schizophrenia bulletin · 2023Article
- Clozapine Reverses Dysfunction of Glutamatergic Neurons Derived From Clozapine-Responsive Schizophrenia Patients.Frontiers in cellular neuroscience · 2022Article
- Changes in Brain Glutamate on Switching to Clozapine in Treatment-Resistant Schizophrenia.Schizophrenia bulletin · 2021Article
- In vivo electrophysiological recordings of the effects of antidepressant drugs.Experimental brain research · 2019Review
- Relationship between glycine transporter 1 inhibition as measured with positron emission tomography and changes in cognitive performances in nonhuman primates.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Antipsychotic drug effects in schizophrenia: a review of longitudinal FMRI investigations and neural interpretations.Current medicinal chemistry · 2013Review
- From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Review
- Effects of aripiprazole, olanzapine, and haloperidol in a model of cognitive deficit of schizophrenia in rats: relationship with glutamate release in the medial prefrontal cortex.Psychopharmacology · 2011Article
- Dopamine release induced by atypical antipsychotics in prefrontal cortex requires 5-HT(1A) receptors but not 5-HT(2A) receptors.The international journal of neuropsychopharmacology · 2010Article
- Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia.BMC neuroscience · 2009Article
- A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration.Frontiers in systems neuroscience · 2009Article
- Orbitofrontal cortex neurons as a common target for classic and glutamatergic antipsychotic drugs.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008Article
- Divergent plasticity of prefrontal cortex networks.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008Review
- NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Clozapine upregulates the expression of the vesicular GABA transporter (VGAT) in rat frontal cortex.Molecular psychiatry · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMechanisms underlying clozapine's better clinical efficacy in schizophrenia remain poorly understood. The prefrontal cortex (PFC) has been implicated as a primary site for the therapeutic effects of clozapine; however, evidence for how clozapine influences the activity of PFC neurons in behaviorally relevant contexts is lacking.
methodsEnsemble single unit recording in awake rats was used to measure the activity of PFC neurons in response to clozapine, its main metabolite N-desmethylclozapine (DMClz), and the typical antipsychotic drug haloperidol during baseline conditions and after treatment with the N-methyl-D-aspartate antagonist MK801. Behavioral stereotypy was scored during recording.
resultsClozapine and DMClz but not haloperidol had an activity-dependent influence on spontaneous firing rate of PFC cells: they increased the activity of neurons with low baseline firing rates and decreased the activity of neurons with higher firing rates. Clozapine and DMClz but not haloperidol also reversed the effect of MK801 on PFC neuronal firing. This reversal was strongly correlated with blockade of MK801-induced behavioral stereotypy.
conclusionsThese findings indicate that clozapine has the capacity to fine-tune spontaneous and disrupted activity of PFC neurons. This effect might contribute, in part, to the therapeutic efficacy of clozapine in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.