Evidence map›Paper›PMID 17045645›Full record

ReviewCell calcium

Calcium microdomains and cell cycle control.

Michael Whitaker

Abstract readReview
In one paragraph

Review in Cell calcium. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 81 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Mitosis, Focus on Calcium.Frontiers in physiology · 2022
    Review
  5. Review
  6. A centrosome-localized calcium signal is essential for mammalian cell mitosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  7. Article
  8. Article
  9. Effect of zero valent iron nanoparticles to Eisenia fetida in three soil types.Environmental science and pollution research international · 2016
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Calcium signaling in the liver.Comprehensive Physiology · 2013
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Cancer as a metabolic disease.Nutrition & metabolism · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Michael WhitakerInstitute of Cell and Molecular Biosciences, Medical School, Framlington Place, Newcastle upon Tyne, UK. michael.whitaker@ncl.ac.uk
Newcastle University · GB

Funding

Wellcome Trust 080374
6 · The paper itself

Abstract

The cell division cycle comprises successive rounds of genome replication and segregation that are never error-free. A complex signalling network chaperones cell cycle events to ensure that cell cycle progression does not occur until any errors detected are put right. The signalling network consists of cell cycle control proteins that are phosphorylated and dephosphorylated, synthesized and degraded interactively to generate a set of sensors and molecular switches that are thrown at appropriate times to permit or trigger cell cycle progression. In early embryos, discrete calcium signals have been shown to be a key component of the molecular switch mechanism. In somatic cells in contrast, the participation of calcium signals in cell cycle control is far from clear. Recent experiments in syncytial Drosophila embryos have shown that localised calcium signals in the nucleus and mitotic spindle can be detected. It appears that the nucleus comprises a calcium signalling microdomain bounded by endoplasmic reticulum that isolates the nucleus and spindle. These findings offer a possible explanation for the apparent absence of calcium signals in somatic cells during mitosis.

Indexed as

AnimalsCalcium SignalingCell CycleCell NucleusDrosophilaEmbryo, NonmammalianEndoplasmic ReticulumMembrane MicrodomainsSpindle Apparatus

Identifiers

PMID17045645
PMCPMC3292880
OpenAlexW2056314482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.