ArticleJournal of molecular histology2006
Expression of genes for gelatinases and tissue inhibitors of metalloproteinases in periodontal tissues during orthodontic tooth movement.
Article in Journal of molecular histology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Effect of orthodontic forces on levels of enzymes in gingival crevicular fluid (GCF): A systematic review.Dental press journal of orthodontics · 2019Pooled it
- Effect of Simvastatin Combined with Photobiomodulation Therapy on Orthodontic Tooth Movement and the Expression of Metalloproteinases and Inhibitors - An Experimental Study.Lasers in medical science · 2025Article
- Effect of 980nm Low-Level Laser Therapy on Matrix Metalloproteinase-1 Levels in Gingival Crevicular Fluid During Fixed Orthodontic Treatment.Journal of lasers in medical sciences · 2025Article
- Matrix Metalloproteinases in Dental and Periodontal Tissues and Their Current Inhibitors: Developmental, Degradational and Pathological Aspects.International journal of molecular sciences · 2022Review
- Using Salivary MMP-9 to Successfully Quantify Periodontal Inflammation during Orthodontic Treatment.Journal of clinical medicine · 2021Article
- MicroRNA-34 expression in gingival crevicular fluid correlated with orthodontic tooth movement.The Angle orthodontist · 2020Article
- Extreme intrusive force affects the expression of c-Fos and matrix metallopeptidase 9 in human dental pulp tissues.Medicine · 2020Article
- A cross-sectional cohort study of gingival crevicular fluid biomarkers in normal-weight and obese subjects during orthodontic treatment with fixed appliances.The Angle orthodontist · 2019Article
- NAMPT expression in osteoblasts controls osteoclast recruitment in alveolar bone remodeling.Journal of cellular physiology · 2018Article
- aMMP-8 in correlation to caries and periodontal condition in adolescents-results of the epidemiologic LIFE child study.Clinical oral investigations · 2018Article
- Novel device for application of continuous mechanical tensile strain to mammalian cells.Biology open · 2017Article
- Combined effect of photobiomodulation with a matrix metalloproteinase inhibitor on the rate of relapse in rats.The Angle orthodontist · 2016Article
- Effects of low-intensity laser therapy on periodontal tissue remodeling during relapse and retention of orthodontically moved teeth.Lasers in medical science · 2013Article
- Binding of amelogenin to MMP-9 and their co-expression in developing mouse teeth.Journal of molecular histology · 2012Article
- Mast cells and MMP-9 in the lamina propria during eruption of rat molars: quantitative and immunohistochemical evaluation.Journal of anatomy · 2010Article
- Anabolic effect of intermittent PTH(1-34) on the local microenvironment during the late phase of periodontal repair in a rat model of tooth root resorption.Clinical oral investigations · 2010Article
- Matrix metalloproteinase 2 activity decreases in human periodontal ligament fibroblast cultures submitted to simulated orthodontic force.In vitro cellular & developmental biology. Animal · 2009Article
- Mechanisms of tooth eruption and orthodontic tooth movement.Journal of dental research · 2008Review
- Expression of matrix metalloproteinases-2 and -9 and RECK during alveolar bone regeneration in rat.Journal of molecular histology · 2008Article
- The effect of laser irradiation and doxycycline application on the production of matrix metalloproteinase-8 and collagen I from cultured human periodontal ligament cells.Dental research journalArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orthodontic tooth movement progresses by a combination of periodontal ligament (PDL) tissue and alveolar bone remodeling processes. Besides the remodeling of alveolar bone around the moving teeth, the major extracellular matrix (ECM) components of PDLs, collagens, are degenerated, degraded, and restructured. Matrix metalloproteinases (MMPs) and their specific inhibitors, tissue inhibitors of metalloproteinases (TIMPs), act in a co-ordinated fashion to regulate the remodeling of periodontal tissues. We hypothesized that the expression levels of the genes for MMP-2, MMP-9, and TIMPs 1-3 are increased transiently in the periodontal tissue during orthodontic tooth movement. To test this hypothesis, we employed an animal model of tooth movement using rats, as well as in situ hybridization to analyze the expression levels of Mmp-2, Mmp-9, and Timps 1-3. The expression levels of these genes increased transiently in cells of periodontal tissues, which include cementoblasts, fibroblasts, osteoblasts, and osteoclasts, at the compression side of the moving teeth. The transient increases in gene expression at the tension side were mainly limited to osteoblasts and cementoblasts. In conclusion, the expression levels of Mmp-2, Mmp-9, and Timps 1-3 increase transiently during orthodontic tooth movement at both the tension and compression sides. The expression of these genes is regulated differentially in the periodontal tissue of the tension side and compression side. This altered pattern of gene expression may determine the rate and extent of remodeling of the collagenous ECM in periodontal tissues during orthodontic tooth movement.
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