ArticlePediatric nephrology (Berlin, Germany)2007
MDR-1 gene polymorphisms and clinical course of steroid-responsive nephrotic syndrome in children.
Article in Pediatric nephrology (Berlin, Germany), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- A PRISMA-compliant meta-analysis of MDR1 polymorphisms and idiopathic nephrotic syndrome: Susceptibility and steroid responsiveness.Medicine · 2017Pooled it
- Everolimus pharmacokinetics and its exposure-toxicity relationship in patients with thyroid cancer.Cancer chemotherapy and pharmacology · 2016Trial
- Pharmacokinetics of prednisolone at steady state in young patients with systemic lupus erythematosus on prednisone therapy: an open-label, single-dose study.Clinical therapeutics · 2011Trial
- Influence of Multidrug Resistance 1 Gene Variants on Response to Intravenous Methylprednisolone Pulse in Systemic Lupus Erythematosus Patients: Preliminary Results.Current rheumatology reviews · 2025Article
- Assessment of the Link ofJournal of advanced research · 2021Article
- Prediction of steroid resistance and steroid dependence in nephrotic syndrome children.Journal of translational medicine · 2021Article
- Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2019Review
- Recipient rs1045642 Polymorphism Is Associated With Office Blood Pressure at 1-Year Post Kidney Transplantation: A Single Center Pharmacogenetic Cohort Pilot Study.Frontiers in pharmacology · 2018Article
- Single Nucleotide Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome.International journal of nephrology · 2016Article
- Differential effects of hydrocortisone, prednisone, and dexamethasone on hormonal and pharmacokinetic profiles: a pilot study in children with congenital adrenal hyperplasia.International journal of pediatric endocrinology · 2016Article
- Effects of theMedical sciences (Basel, Switzerland) · 2015Article
- MDR1 polymorphisms and idiopathic nephrotic syndrome in Slovak children: preliminary results.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Pharmacogenetics and pharmacogenomics in rheumatology.Immunologic research · 2013Review
- Screening for urinary biomarkers of steroid-resistant nephrotic syndrome in children.Experimental and therapeutic medicine · 2013Article
- Genetic variability and haplotype profile of MDR1 in Saudi Arabian males.Molecular biology reports · 2012Article
- Genetic polymorphisms influence the steroid treatment of children with idiopathic nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2012Article
- Polymorphisms of the MDR1 and MIF genes in children with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2011Article
- Effect of MDR1 C3435T polymorphism on lansoprazole in healthy Japanese subjects.European journal of clinical pharmacology · 2009Article
- A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function.Biochimica et biophysica acta · 2009Review
- Glutathione-S-transferase-P1 I105V polymorphism and response to antenatal betamethasone in the prevention of respiratory distress syndrome.European journal of clinical pharmacology · 2009Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study was aimed at investigating the association between MDR-1 genetic polymorphisms [C1236T, G2677T(A), C3435T] and parameters describing the clinical course and treatment response of childhood steroid-responsive nephrotic syndrome (SRNS). Three MDR-1 genetic markers were analyzed in 108 children diagnosed with SRNS and in 135 healthy controls with neither allergic nor renal disease. All subjects were genotyped by PCR-restriction fragment length polymorphism (RFLP) analysis, and an EM algorithm-based analysis was utilized to estimate haplotype frequencies. As expected, there was no difference in genotypic and allelic distribution between and among SRNS patients and healthy children. However, all individual polymorphisms were strongly associated with time to response to initial prednisone therapy. The frequencies of the mutated alleles were higher in late responders (time to remission: >7 days) to oral prednisone (0.53, 0.52,0.66) than in early responders (time to remission: <7 days; 0.24, 0.19, 0.32), with all p values <0.001 for positions 1236, 2677 and 3435, respectively). Odds ratios (ORs) reflecting the strength of the associations were as follows: 6.79 (95% CI:1.96- 23.54) for 1236 T/T, 13.7 (95% CI:2.78-67) for 2677 T/T and 9.92 (95% CI: 3.01-32.71) for 3435 T/T as compared to the respective-wild type homozygotes. The TTT haplotype was similarly found to be significantly associated with late oral steroid response (0.49 vs. 0.19, p=0.0003). Variants 1236T, 2677TA and 3435T identify patients that respond slower to oral prednisone. Although the functional properties of the substitutions investigated here are still to be determined, our findings may be a small step toward the optimization of immunosuppressive therapy in SRNS children.
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