ArticleMolecular psychiatry2007
Violent behavior associated with hypocholesterolemia due to a novel APOB gene mutation.
Article in Molecular psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 42 citations in OpenAlex.
- Novel protein-truncating variant in theAtherosclerosis plus · 2022Article
- A Rare Mutation in TheInternational journal of molecular sciences · 2020Article
- Prevalence of hypobetalipoproteinemia and related psychiatric characteristics in a psychiatric population: results from the retrospective HYPOPSY Study.Lipids in health and disease · 2018Article
- The NADPH oxidase NOX2 as a novel biomarker for suicidality: evidence from human post mortem brain samples.Translational psychiatry · 2016Article
- An overview of the neurobiology of suicidal behaviors as one meta-system.Molecular psychiatry · 2015Review
- Biomarker identification and effect estimation on schizophrenia - a high dimensional data analysis.Frontiers in public health · 2015Article
- Low cholesterol, delinquency, and suicidality.Primary care companion to the Journal of clinical psychiatry · 2008Article
- Vigilance needed in recognizing behavior changes in patients taking statins.Primary care companion to the Journal of clinical psychiatry · 2008Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 26-year-old male, the index patient, presented with persecutory delusions and suicidal behavior. He had 10 paternal male relatives in two prior generations. Five of them died by violent suicide and one, of the five, also committed a double homicide. The index patient was found to be hypocholesterolemic due to being heterozygous for a novel mutation of apolipoprotein B (apoB-29.4). His mother and paternal grandmother were normocholesterolemic, whereas a surviving paternal uncle was hypocholesterolemic and heterozygous for the apoB-29.4 mutation. This indicated that the index patient's father and paternal grandfather, both of which died by violent suicide, were obligate heterozygotes for the apoB-29.4 mutation and that the index patient inherited the mutation from his paternal grandfather. The odds ratio for the association between hypocholesterolemia and violent behavior in this family, where cholesterol status was known, was 16.9 (95% confidence interval 1.1-239.3). Therefore, our results support an inheritable relationship between violent behavior and hypocholesterolemia.
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