ArticleOncogene2007
Regulation of clustered gene expression by cofactor of BRCA1 (COBRA1) in breast cancer cells.
Article in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Role of NELF-B in supporting epithelial-mesenchymal transition and cell proliferation during hepatocellular carcinoma progression.Oncology letters · 2021Article
- BRCA1 Interacting Protein COBRA1 Facilitates Adaptation to Castrate-Resistant Growth Conditions.International journal of molecular sciences · 2018Article
- Expression of cancer testis antigens in human BRCA-associated breast cancers: potential targets for immunoprevention?Cancer immunology, immunotherapy : CII · 2011Article
- Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II.Nature neuroscience · 2011Article
- Cell density-dependent transcriptional activation of endocrine-related genes in human adipose tissue-derived stem cells.Experimental cell research · 2010Article
- Human negative elongation factor activates transcription and regulates alternative transcription initiation.The Journal of biological chemistry · 2010Article
- Postrecruitment regulation of RNA polymerase II directs rapid signaling responses at the promoters of estrogen target genes.Molecular and cellular biology · 2009Article
- Promoter proximal pausing on genes in metazoans.Chromosoma · 2009Review
- Genome-wide analysis of alternative promoters of human genes using a custom promoter tiling array.BMC genomics · 2008Article
- NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly.Genes & development · 2008Article
- Deregulation of cofactor of BRCA1 expression in breast cancer cells.Journal of cellular biochemistry · 2008Article
- Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells.International journal of biological sciences · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Eucaryotic genes that are coordinately expressed tend to be clustered. Furthermore, gene clusters across chromosomal regions are often upregulated in various tumors. However, relatively little is known about how gene clusters are coordinately expressed in physiological or pathological conditions. Cofactor of BRCA1 (COBRA1), a subunit of the human negative elongation factor, has been shown to repress estrogen-stimulated transcription of trefoil factor 1 (TFF1 or pS2) by stalling RNA polymerase II. Here, we carried out a genome-wide study to identify additional physiological target genes of COBRA1 in breast cancer cells. The study identified a total of 134 genes that were either activated or repressed upon small hairpin RNA-mediated reduction of COBRA1. Interestingly, many COBRA1-regulated genes reside as clusters on the chromosomes and have been previously implicated in cancer development. Detailed examination of two such clusters on chromosome 21 (21q22) and chromosome X (Xp11) reveals that COBRA1 is physically associated with a subset of its regulated genes in each cluster. In addition, COBRA1 was shown to regulate both estrogen-dependent and -independent transcription of the gene cluster at 21q22, which encompasses the previously identified COBRA1-regulated TFF1 (pS2) locus. Thus, COBRA1 plays a critical role in the regulation of clustered gene expression at preferred chromosomal domains in breast cancer cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.