ArticleProceedings of the National Academy of Sciences of the United States of America2006
Modular chemical mechanism predicts spatiotemporal dynamics of initiation in the complex network of hemostasis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 76 citations in OpenAlex.
- In silico analysis of patient specific coagulation and flow effects on fibrin clot formation.Scientific reports · 2026Article
- Biophysical perspectives of the spatiotemporal dynamics of plasma coagulation under flow.Biophysical reviews · 2025Review
- Thrombosis and Hemodynamics: external and intrathrombus gradients.Current opinion in biomedical engineering · 2021Article
- Modeling Thrombin Generation in Plasma under Diffusion and Flow.Biophysical journal · 2020Article
- A mathematical model of coagulation under flow identifies factor V as a modifier of thrombin generation in hemophilia A.Journal of thrombosis and haemostasis : JTH · 2020Article
- Article
- Conceptual and Experimental Tools to Understand Spatial Effects and Transport Phenomena in Nonlinear Biochemical Networks Illustrated with Patchy Switching.Annual review of biochemistry · 2017Review
- Localization of Short-Chain Polyphosphate Enhances its Ability to Clot Flowing Blood Plasma.Scientific reports · 2017Article
- Blood flow and mass transfer regulation of coagulation.Blood reviews · 2016Review
- Minimum wound size for clotting: flowing blood coagulates on a single collagen fiber presenting tissue factor and von Willebrand factor.Integrative biology : quantitative biosciences from nano to macro · 2016Article
- Simulated thrombin responses in venous valves.Journal of vascular surgery. Venous and lymphatic disorders · 2016Article
- Transport physics and biorheology in the setting of hemostasis and thrombosis.Journal of thrombosis and haemostasis : JTH · 2016Review
- Simulated Thrombin Generation in the Presence of Surface-Bound Heparin and Circulating Tissue Factor.Annals of biomedical engineering · 2016Article
- Emerging microengineered tools for functional analysis and phenotyping of blood cells.Trends in biotechnology · 2014Review
- Measuring fate and rate of single-molecule competition of amplification and restriction digestion, and its use for rapid genotyping tested with hepatitis C viral RNA.Angewandte Chemie (International ed. in English) · 2014Article
- The use of microfluidics in hemostasis: clinical diagnostics and biomimetic models of vascular injury.Current opinion in hematology · 2013Review
- Systems biology of coagulation.Journal of thrombosis and haemostasis : JTH · 2013Review
- A novel μ-fluidic whole blood coagulation assay based on Rayleigh surface-acoustic waves as a point-of-care method to detect anticoagulants.Biomicrofluidics · 2013Article
- The role of fibrinogen spacing and patch size on platelet adhesion under flow.Acta biomaterialia · 2012Article
- Complex function by design using spatially pre-structured synthetic microbial communities: degradation of pentachlorophenol in the presence of Hg(ii).Integrative biology : quantitative biosciences from nano to macro · 2011Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article demonstrates that a simple chemical model system, built by using a modular approach, may be used to predict the spatiotemporal dynamics of initiation of blood clotting in the complex network of hemostasis. Microfluidics was used to create in vitro environments that expose both the complex network and the model system to surfaces patterned with patches presenting clotting stimuli. Both systems displayed a threshold response, with clotting initiating only on isolated patches larger than a threshold size. The magnitude of the threshold patch size for both systems was described by the Damköhler number, measuring competition of reaction and diffusion. Reaction produces activators at the patch, and diffusion removes activators from the patch. The chemical model made additional predictions that were validated experimentally with human blood plasma. These experiments show that blood can be exposed to significant amounts of clot-inducing stimuli, such as tissue factor, without initiating clotting. Overall, these results demonstrate that such chemical model systems, implemented with microfluidics, may be used to predict spatiotemporal dynamics of complex biochemical networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.