ArticleProceedings of the National Academy of Sciences of the United States of America2006
Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- The antihypertensive action of C-phycocyanin is related to the prevention of angiotensin II-caused vascular dysfunction in chronic kidney disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting.Pharmacological reviews · 2022Review
- AT2 receptor interacting protein 1 (ATIP1) mediates COX-2 induction by an AT2 receptor agonist in endothelial cells.Biochemistry and biophysics reports · 2020Article
- "I don't get no respect": the role of chloride in acute kidney injury.American journal of physiology. Renal physiology · 2019Review
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- IL-4/IL-13-mediated polarization of renal macrophages/dendritic cells to an M2a phenotype is essential for recovery from acute kidney injury.Kidney international · 2017Article
- Interaction of the renin angiotensin and cox systems in the kidney.Frontiers in bioscience (Scholar edition) · 2016Review
- Proximal tubule-derived colony stimulating factor-1 mediates polarization of renal macrophages and dendritic cells, and recovery in acute kidney injury.Kidney international · 2015Article
- Inhibition of cyclooxygenase-2 in hematopoietic cells results in salt-sensitive hypertension.The Journal of clinical investigation · 2015Article
- Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis.Oncotarget · 2015Article
- Hypohalous acids contribute to renal extracellular matrix damage in experimental diabetes.Diabetes · 2015Article
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- Down-regulation of cyclooxygenase-2 by the carboxyl tail of the angiotensin II type 1 receptor.The Journal of biological chemistry · 2014Article
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- Glucocorticoid modulates angiotensin II receptor expression patterns and protects the heart from ischemia and reperfusion injury.PloS one · 2014Article
- Epithelial-specific deletion of 11β-HSD2 hinders Apcmin/+ mouse tumorigenesis.Molecular cancer research : MCR · 2013Article
- Physiologic and pathophysiologic roles of cyclooxygenase-2 in the kidney.Transactions of the American Clinical and Climatological Association · 2013Article
- CSF-1 signaling mediates recovery from acute kidney injury.The Journal of clinical investigation · 2012Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Macula densa cyclooxygenase 2 (COX-2)-derived prostaglandins serve as important modulators of the renin-angiotensin system, and cross-talk exists between these two systems. Cortical COX-2 induction by angiotensin-converting enzyme (ACE) inhibitors or AT(1) receptor blockers (ARBs) suggests that angiotensin II may inhibit cortical COX-2 by stimulating the AT(1) receptor pathway. In the present studies we determined that chronic infusion of either hypertensive or nonhypertensive concentrations of angiotensin II attenuated cortical COX-2. Angiotensin II infusion reversed cortical COX-2 elevation induced by ACE inhibitors. However, we found that angiotensin II infusion further stimulated cortical COX-2 elevation induced by ARBs, suggesting a potential role for an AT(2) receptor-mediated pathway when the AT(1) receptor was inhibited. Both WT and AT(2) receptor knockout mice were treated for 7 days with either ACE inhibitors or ARBs. Cortical COX-2 increased to similar levels in response to ACE inhibition in both knockout and WT mice. In WT mice ARBs increased cortical COX-2 more than ACE inhibitors, and this stimulation was attenuated by the AT(2) receptor antagonist PD123319. In the knockout mice ARBs led to significantly less cortical COX-2 elevation, which was not attenuated by PD123319. PCR confirmed AT(1a) and AT(2) receptor expression in the cultured macula densa cell line MMDD1. Angiotensin II inhibited MMDD1 COX-2, and CGP42112A, an AT(2) receptor agonist, stimulated MMDD1 COX-2. In summary, these results demonstrate that macula densa COX-2 expression is oppositely regulated by AT(1) and AT(2) receptors and suggest that AT(2) receptor-mediated cortical COX-2 elevation may mediate physiologic effects that modulate AT(1)-mediated responses.
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