ArticleProceedings of the National Academy of Sciences of the United States of America2006
UV irradiation induces a postreplication DNA damage checkpoint.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed.
- LncRNA LIMp27 Regulates the DNA Damage Response through p27 in p53-Defective Cancer Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Article
- Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters.eLife · 2022Article
- Smc5/6 Complex Promotes Rad3Molecular and cellular biology · 2022Article
- Checkpoint functions of RecQ helicases at perturbed DNA replication fork.Current genetics · 2021Review
- AMolecular and cellular biology · 2019Article
- Right time, right place-DNA damage and DNA replication checkpoints collectively safeguard S phase.The EMBO journal · 2018Review
- Lesion Bypass and the Reactivation of Stalled Replication Forks.Annual review of biochemistry · 2018Review
- Spatial separation between replisome- and template-induced replication stress signaling.The EMBO journal · 2018Article
- Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours around the Same Obstacle.Chemical reviews · 2017Review
- Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA.Biochemistry · 2017Article
- Article
- Coordination of DNA damage tolerance mechanisms with cell cycle progression in fission yeast.Cell cycle (Georgetown, Tex.) · 2016Article
- Potential relationship between inadequate response to DNA damage and development of myelodysplastic syndrome.International journal of molecular sciences · 2015Review
- Article
- Repriming of DNA synthesis at stalled replication forks by human PrimPol.Nature structural & molecular biology · 2013Article
- PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome.Molecular cell · 2013Article
- PrimPol, an archaic primase/polymerase operating in human cells.Molecular cell · 2013Article
- Article
- Myelodysplastic syndrome: an inability to appropriately respond to damaged DNA?Experimental hematology · 2013Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic cells irradiated with high doses of UV exhibit cell-cycle responses referred to as G(1)/S, intraS, and G(2)/M checkpoints. After a moderate UV dose that approximates sunlight exposure and is lethal to fission yeast checkpoint mutants, we found unexpectedly that these cell-cycle responses do not occur. Instead, cells at all stages of the cell cycle carry lesions into S phase and delay cell-cycle progression for hours after the completion of bulk DNA synthesis. Both DNA replication and the checkpoint kinase, Chk1, are required to generate this cell-cycle response. UV-irradiation of Deltachk1 cells causes chromosome damage and loss of viability only after cells have replicated irradiated DNA and entered mitosis. These data suggest that an important physiological role of the cell-cycle response to UV is to provide time for postreplication repair.
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