ArticleThe Journal of general physiology2006
Cross talk between activation and slow inactivation gates of Shaker potassium channels.
Article in The Journal of general physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 83 citations in OpenAlex.
- Gating crosstalk in potassium channels.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dynamical Nonequilibrium Molecular Dynamics Simulations Reveal Atomistic Steps of C-Type Inactivation in Cardiac hERG Channels.Journal of the American Chemical Society · 2026Article
- Closed state structure of the pore revealed by uncoupled Shaker KNature communications · 2025Article
- Structure of the voltage-gated potassium channel KChannels (Austin, Tex.) · 2023Review
- Interactions between selectivity filter and pore helix control filter gating in the MthK channel.The Journal of general physiology · 2023Article
- Molecular rearrangements in S6 during slow inactivation in Shaker-IR potassium channels.The Journal of general physiology · 2023Article
- The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels.Science advances · 2022Article
- A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V.Nature communications · 2022Article
- Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels.Frontiers in pharmacology · 2022Review
- Structures of Gating Intermediates in a KJournal of molecular biology · 2021Article
- Computational study of non-conductive selectivity filter conformations and C-type inactivation in a voltage-dependent potassium channel.The Journal of general physiology · 2021Article
- Shaker-IR K+ channel gating in heavy water: Role of structural water molecules in inactivation.The Journal of general physiology · 2021Article
- Exploring KFrontiers in molecular biosciences · 2021Article
- Mechanism of C-type inactivation in the hERG potassium channel.Science advances · 2021Article
- The activation gate controls steady-state inactivation and recovery from inactivation in Shaker.The Journal of general physiology · 2020Article
- Flow and shortcuts along the Shaker Kv channel slow inactivation gating cycle.The Journal of general physiology · 2020Article
- The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels.Biophysical journal · 2020Article
- Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling.Nature communications · 2019Article
- Structural and Functional Analyses of Cone Snail Toxins.Marine drugs · 2019Review
- A Selectivity Filter Gate Controls Voltage-Gated Calcium Channel Calcium-Dependent Inactivation.Neuron · 2019Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
This study addresses the energetic coupling between the activation and slow inactivation gates of Shaker potassium channels. To track the status of the activation gate in inactivated channels that are nonconducting, we used two functional assays: the accessibility of a cysteine residue engineered into the protein lining the pore cavity (V474C) and the liberation by depolarization of a Cs(+) ion trapped behind the closed activation gate. We determined that the rate of activation gate movement depends on the state of the inactivation gate. A closed inactivation gate favors faster opening and slower closing of the activation gate. We also show that hyperpolarization closes the activation gate long before a channel recovers from inactivation. Because activation and slow inactivation are ubiquitous gating processes in potassium channels, the cross talk between them is likely to be a fundamental factor in controlling ion flux across membranes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.