ArticleMolecular and cellular biology2007
Drosophila dCBP is involved in establishing the DNA replication checkpoint.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- A role of the Trx-G complex in Cid/CENP-A deposition at Drosophila melanogaster centromeres.Chromosoma · 2019Article
- Social Context Enhances Hormonal Modulation of Pheromone Detection in Drosophila.Current biology : CB · 2019Article
- Quantitative Measurement of Histone Tail Acetylation Reveals Stage-Specific Regulation and Response to Environmental Changes during Drosophila Development.Biochemistry · 2016Article
- CBP binding outside of promoters and enhancers in Drosophila melanogaster.Epigenetics & chromatin · 2015Article
- Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders.Current pharmaceutical design · 2013Review
- Article
- Defining genetic factors that modulate intergenerational CAG repeat instability in Drosophila melanogaster.Genetics · 2011Article
- CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation.The EMBO journal · 2010Article
- Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.Epigenetics · 2010Review
- CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing.Development (Cambridge, England) · 2009Article
- Recognition of double strand breaks by a mutator protein (MU2) in Drosophila melanogaster.PLoS genetics · 2009Article
- Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system.Molecular and cellular biology · 2009Article
- Heterochromatin-mediated gene silencing is not affected by Drosophila CBP activity.The Journal of heredityArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The CBP/p300 family of proteins comprises related acetyltransferases that coactivate signal-responsive transcription. Recent evidence suggests that p300/CBP may also interact directly with complexes that mediate different aspects of DNA metabolism such as replication and repair. In this report, we show that loss of dCBP in Drosophila cells and eye discs results in a defect in the cell cycle arrest induced by stalled DNA replication. We show that dCBP and the checkpoint kinase Mei-41 can be found together in a complex and, furthermore, that dCBP has a genetic interaction with mei-41 in the response to stalled DNA replication. These observations suggest a broader role for the p300/CBP acetyltransferases in the modulation of chromatin structure and function during DNA metabolic events as well as for transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.