ArticleInfection and immunity2007
Dendritic cell-derived exosomes express a Streptococcus pneumoniae capsular polysaccharide type 14 cross-reactive antigen that induces protective immunoglobulin responses against pneumococcal infection in mice.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 65 citations in OpenAlex.
- Hijacking Host Communication: The Central Role of Extracellular Vesicles in Infectious Disease Pathogenesis.Cells · 2026Review
- The 'sugar' side of extracellular vesicle-glycome: a panorama from basic characteristics, deciphering technologies, functions, to applications.Journal of nanobiotechnology · 2026Review
- Molecular Mechanisms of Priming Innate Immunity by Small Extracellular Vesicles Released during Infection with Gram-negative Bacteria.bioRxiv : the preprint server for biology · 2025Article
- Extracellular vesicles and endothelial dysfunction in infectious diseases.Journal of extracellular biology · 2024Review
- Harnessing galactose oxidase in the development of a chemoenzymatic platform for glycoconjugate vaccine design.The Journal of biological chemistry · 2022Article
- Exosomal miRNAs in the plasma ofFrontiers in immunology · 2022Article
- Current understanding of extracellular vesicle homing/tropism.Zoonoses (Shannon, Ireland) · 2022Article
- Emerging Roles of Extracellular Vesicles in Pneumococcal Infections: Immunomodulators to Potential Novel Vaccine Candidates.Frontiers in cellular and infection microbiology · 2022Review
- Review
- Article
- A brief history of nearly EV-erything - The rise and rise of extracellular vesicles.Journal of extracellular vesicles · 2021Review
- Mesenchymal Stromal/Stem Cells-Derived Exosomes as an Antimicrobial Weapon for Orodental Infections.Frontiers in microbiology · 2021Review
- Emerging Role of Exosomes in Diagnosis and Treatment of Infectious and Inflammatory Bowel Diseases.Cells · 2020Review
- TBC1D3 regulates the payload and biological activity of extracellular vesicles that mediate tissue repair.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Exosome mediated multidrug resistance in cancer.American journal of cancer research · 2018Review
- An immunoregulatory role of dendritic cell-derived exosomes versus HIV-1 infection: take it easy but be warned.Annals of translational medicine · 2017Article
- Quantitative Proteomics of Cerebrospinal Fluid in Paediatric Pneumococcal Meningitis.Scientific reports · 2017Article
- Identification of the binding roles of terminal and internal glycan epitopes using enzymatically synthesized N-glycans containing tandem epitopes.Organic & biomolecular chemistry · 2016Article
- Extracellular vesicles and infectious diseases: new complexity to an old story.The Journal of clinical investigation · 2016Review
- Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples.Journal of extracellular vesicles · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Exosomes activate T cells in vivo, but whether exosomes are able to induce humoral immune responses is still unknown. We found that dendritic cells, but not other immune cells, constitutively release an exosome-associated glycoconjugate that is cross-reactive with the capsular polysaccharide of Streptococcus pneumoniae type 14 (Cps14-CRA). Cps14-CRA was localized to the cholesterol-enriched microdomains or rafts of the exosomes and was mapped to the beta1-->6 branched N-acetyl-lactosamine derivatives of the Cps14-CRA. Injection of CFA-primed naive mice with purified dendritic cell exosomes induced immunoglobulin (Ig) anti-Cps14 responses composed predominantly of IgM, IgG3, and IgG1. These responses were associated with protection against a lethal challenge with live S. pneumoniae type 14, but not with type 3 bacteria, and was correlated with the titer of elicited IgM and IgG3 anti-Cps14. These data show, for the first time, that exosomes can induce a humoral immune response to an associated unprocessed, autologous antigen. Although anti-Cps14 Ig responses are specifically demonstrated, these could reflect a broader mechanism that modulates both natural immunity and autoimmunity to other glycotopes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.