ArticleClinical and experimental immunology1991
The complement-inhibiting protein, protectin (CD59 antigen), is present and functionally active on glomerular epithelial cells.
Article in Clinical and experimental immunology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 48 citations in OpenAlex.
- Complement expression profiles in human glomerular mesangial cells, endothelial cells, podocytes and proximal tubular epithelial cells.Frontiers in immunology · 2026Article
- In Vivo Assessment of Laboratory-Grown Kidney Tissue Grafts.Bioengineering (Basel, Switzerland) · 2023Article
- Shiga toxin 2 reduces complement inhibitor CD59 expression on human renal tubular epithelial and glomerular endothelial cells.Infection and immunity · 2013Article
- A compendium of urinary biomarkers indicative of glomerular podocytopathy.Pathology research international · 2013Review
- Post testicular sperm maturational changes in the bull: important role of the epididymosomes and prostasomes.Veterinary medicine international · 2010Article
- Upregulation of CD59: potential mechanism of accommodation in a large animal model.Transplantation · 2009Article
- Experimental membranous nephropathy redux.American journal of physiology. Renal physiology · 2005Review
- Membrane attack complex of complement and 20 kDa homologous restriction factor (CD59) in myocardial infarction.Virchows Archiv : an international journal of pathology · 1997Article
- Structural composition and functional characterization of soluble CD59: heterogeneity of the oligosaccharide and glycophosphoinositol (GPI) anchor revealed by laser-desorption mass spectrometric analysis.The Biochemical journal · 1996Article
- Membrane proteins that protect against complement lysis.Springer seminars in immunopathology · 1994Review
- Expression of CD59, a complement regulator protein and a second ligand of the CD2 molecule, and CD46 in normal and neoplastic colorectal epithelium.British journal of cancer · 1993Article
- Immunolocalization and characterization of the rat analogue of human CD59 in kidney and glomerular cells.Immunology · 1993Article
- Article
- Membrane defence against complement lysis: the structure and biological properties of CD59.Immunologic research · 1993Review
- Characterization of the membrane attack complex inhibitory protein CD59 antigen on human amniotic cells and in amniotic fluid.Immunology · 1992Article
- Isolation and characterization of the complement-inhibiting protein CD59 antigen from platelet membranes.The Biochemical journal · 1992Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
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Abstract
Protectin (CD59 antigen) is a 20-kD phosphatidyl-inositol-linked membrane protein that inhibits formation of the membrane attack complex (MAC) of complement on homologous cells. Although the antigen has been identified in a number of human tissues, until recently a functional role had been demonstrated only in circulating cells. Using immunofluorescence techniques we have shown the presence of protectin on human glomerular epithelial cells (GEC) in culture and on GEC, tubular epithelial cells and endothelial cells in frozen sections of normal human renal cortex. In addition, we present evidence that this protein functions in protection of GEC from homologous complement: cultured cells incubated with the Fab2 fragment of a monoclonal anti-protein antibody were markedly more susceptible to killing by homologous serum than were cells in the absence of Fab2 anti-protectin. These findings suggest that this protein may be important in the maintenance of glomerular integrity in vivo, and may be of relevance in certain renal diseases.
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