ReviewParasite immunology2006
Helminths and HIV infection: epidemiological observations on immunological hypotheses.
Review in Parasite immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00817713 (Can Anthelminthic Treatment Delay the Progression of HIV? Randomised Open-label Trial Testing Presumptive Anthelminthic Treatment on Progression of HIV in ART-naïve HIV-positive Patients in a Rural African Setting With Presumed High Prevalence of Helminth Infections.), which is not on this map. Cited by 38 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Can Anthelminthic Treatment Delay the Progression of HIV? Randomised Open-label Trial Testing Presumptive Anthelminthic Treatment on Progression of HIV in ART-naïve HIV-positive Patients in a Rural African Setting With Presumed High Prevalence of Helminth Infections.
Who cites it
38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Prevalence of soil-transmitted helminth infections in HIV patients: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Antihelminthics in helminth-endemic areas: effects on HIV disease progression.The Cochrane database of systematic reviews · 2016Pooled it
- Deworming helminth co-infected individuals for delaying HIV disease progression.The Cochrane database of systematic reviews · 2009Pooled it
- Treatment of helminth co-infection in HIV-1 infected individuals in resource-limited settings.The Cochrane database of systematic reviews · 2008Pooled it
- Treatment of helminth co-infection in individuals with HIV-1: A systematic review of the literature.PLoS neglected tropical diseases · 2007Pooled it
- Changes in plasma cytokines after treatment of ascaris lumbricoides infection in individuals with HIV-1 infection.The Journal of infectious diseases · 2010Trial
- Prevalence and correlates of helminth co-infection in Kenyan HIV-1 infected adults.PLoS neglected tropical diseases · 2010Trial
- Albendazole treatment of HIV-1 and helminth co-infection: a randomized, double-blind, placebo-controlled trial.AIDS (London, England) · 2008Trial
- Intracellular Parasitic Infections Caused byVaccines · 2025Review
- Efficiency of anthelmintic treatment and its effect on microparasite dynamics in wildInternational journal for parasitology. Parasites and wildlife · 2025Article
- Molecular mechanisms of co-infections.EMBO reports · 2025Review
- HIV-Helminth Co-Infections and Immune Checkpoints: Implications for Cancer Risk in South Africa.Viruses · 2025Article
- The Impact of HIV and Parasite Single Infection and Coinfection on Telomere Length: A Systematic Review.Current issues in molecular biology · 2024Review
- Soil-transmitted helminths: A critical review of the impact of co-infections and implications for control and elimination.PLoS neglected tropical diseases · 2023Review
- Review
- The Potential Nexus between Helminths and SARS-CoV-2 Infection: A Literature Review.Journal of immunology research · 2023Review
- Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and Diseases.Journal of immunology research · 2022Review
- Prevalence and Intensity ofResearch and reports in tropical medicine · 2021Article
- Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro.PLoS pathogens · 2019Article
- Schistosoma and Other Relevant Helminth Infections in HIV-Positive Individuals-an Overview.Tropical medicine and infectious disease · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Parasitic helminths have co-evolved with the mammalian immune system. Current hypotheses suggest that immunological stimulation in the presence of helminths is balanced by immuno-regulation and by the broad spectrum of mechanisms possessed by helminths for countering the host immune response. The degree to which this balance is perfected, and the mechanisms by which this is achieved, vary between helminth species; we suggest that this is reflected not only in the degree of pathology induced by helminths but also in a variety of relationships with HIV infection and HIV disease. Available epidemiological data regarding interactions between helminths and HIV are largely observational; results are variable and generally inconclusive. Well designed, controlled intervention studies are required to provide definitive information on the species-specific nature of these interactions and on the advantages, disadvantages and optimal timing of de-worming in relation to HIV infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.