Evidence map›Paper›PMID 1704192›Full record

ArticleThe American journal of pathology1991

Enhanced expression of neural cell adhesion molecules and tenascin (cytotactin) during wound healing.

C M Chuong, H M Chen

Open access · greenAbstract read
In one paragraph

Article in The American journal of pathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 110 citations in OpenAlex.

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  20. Tenascin-C and human tendon degeneration.The American journal of pathology · 1996
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

C M ChuongDepartment of Pathology, School of Medicine, University of Southern California, Los Angeles 90033.
H M Chen
University of Southern California · US

Funding

LIMB CHONDROGENESISR01HD024301 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUONG, CHENG-MING · 1988 to 1992
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NICHD NIH HHS HD 24301
6 · The paper itself

Abstract

Both neural cell adhesion molecules (N-CAM) and tenascin (cytotactin) are important in embryonic morphogenesis but their expression is reduced greatly in adults. This study examined whether they are induced during wound healing. The spatial and temporal expression patterns of these two and other adhesion molecules in the healing of skin, cartilage, and tendon were compared. Neural cell adhesion molecules, tenascin, and fibronectin are induced in the granulation tissue but the order of prevalence is fibronectin, tenascin, N-CAM. The order of appearance is N-CAM and fibronectin, and then tenascin. The order of disappearance is N-CAM, tenascin, fibronectin. Liver cell adhesion molecules are present in the epidermis undergoing re-epithelization. Explant cultures showed that N-CAM and tenascin are synthesized by wound fibroblasts. These results suggest that N-CAM and tenascin, widely used in embryonic morphogenesis, are induced in a variety of connective tissues during wound healing.

Indexed as

AnimalsCell AdhesionCell Adhesion MoleculesCell Adhesion Molecules, NeuronalChickensConnective TissueCulture TechniquesExtracellular Matrix ProteinsFibronectinsLiverMiceMice, Inbred StrainsSkinStomachSuturesTenascinCell Adhesion MoleculesCell Adhesion Molecules, NeuronalExtracellular Matrix ProteinsFibronectinsTenascin

Identifiers

PMID1704192
PMCPMC1886190
OpenAlexW1883473411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.