ArticleApoptosis : an international journal on programmed cell death2006
Signaling through the TRAIL receptor DR5/FADD pathway plays a role in the apoptosis associated with skeletal myoblast differentiation.
Article in Apoptosis : an international journal on programmed cell death, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- DHA Induces Cell Death through the Production of ROS and the Upregulation of CHOP in Fibroblast-like Synovial Cells from Human Rheumatoid Arthritis Patients.International journal of molecular sciences · 2023Article
- TRAIL/DR5 pathway promotes AKT phosphorylation, skeletal muscle differentiation, and glucose uptake.Cell death & disease · 2021Article
- Muscle-derived TRAIL negatively regulates myogenic differentiation.Experimental cell research · 2020Article
- Basal Signalling Through Death Receptor 5 and Caspase 3 Activates p38 Kinase to Regulate Serum Response Factor (SRF)-Mediated MyoD Transcription.Journal of molecular signaling · 2020Article
- Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity.British journal of pharmacology · 2015Article
- IRES-mediated translation of the pro-apoptotic Bcl2 family member PUMA.Translation (Austin, Tex.) · 2013Article
- Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion.Recent patents on anti-cancer drug discovery · 2011Review
- Multilocus association testing of quantitative traits based on partial least-squares analysis.PloS one · 2011Article
- Puma and Trail/Dr5 pathways control radiation-induced apoptosis in distinct populations of testicular progenitors.PloS one · 2010Article
- Non-canonical role for the TRAIL receptor DR5/FADD/caspase pathway in the regulation of MyoD expression and skeletal myoblast differentiation.Differentiation; research in biological diversity · 2009Article
- Phospho-ablated Id2 is growth suppressive and pro-apoptotic in proliferating myoblasts.PloS one · 2009Article
- Prostaglandin F2alpha promotes muscle cell survival and growth through upregulation of the inhibitor of apoptosis protein BRUCE.Cell death and differentiation · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Apoptosis rather than differentiation is a physiological process during myogenesis and muscle regeneration. When cultured myoblasts were induced to differentiate, we detected an increase in caspase 8 activity. Pharmacological inhibition of caspase 8 activity decreased apoptosis. Expression of a dominant-negative mutant of the adapter protein FADD also abrogated apoptosis, implicating a death ligand pathway. Treatment with TRAIL, but not Fas, induced apoptosis in these myoblasts. Accordingly, treatment with a soluble TRAIL decoy receptor or expression of a dominant-negative mutant of the TRAIL receptor DR5 abrogated apoptosis. While TRAIL expression levels remained unaltered in apoptotic myoblasts, DR5 expression levels increased. Finally, we also detected a reduction in FLIP, a death-receptor effector protein and caspase 8 competitive inhibitor, to undetectable levels in apoptotic myoblasts. Thus, our data demonstrate an important role for the TRAIL/DR5/FADD/caspase 8 pathway in the apoptosis associated with skeletal myoblast differentiation. Identifying the functional apoptotic pathways in skeletal myoblasts may prove useful in minimizing the myoblast apoptosis that contributes pathologically to a variety of diseases and in minimizing the apoptosis of transplanted myoblasts to treat these and other disease states.
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Registered trials
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