ArticleEukaryotic cell2006
Pheromone-induced degradation of Ste12 contributes to signal attenuation and the specificity of developmental fate.
Article in Eukaryotic cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Kar4 acts as a Ste12 regulator inbioRxiv : the preprint server for biology · 2025Article
- Article
- Evaluation and comparison of colorimetric outputs for yeast-based biosensors in laboratory and point-of-use settings.FEMS microbiology letters · 2024Article
- A predictive model of gene expression reveals the role of network motifs in the mating response of yeast.Science signaling · 2021Article
- Identifying genetic modulators of the connectivity between transcription factors and their transcriptional targets.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Pheromone-induced morphogenesis and gradient tracking are dependent on the MAPK Fus3 binding to Gα.Molecular biology of the cell · 2015Article
- Ras protein/cAMP-dependent protein kinase signaling is negatively regulated by a deubiquitinating enzyme, Ubp3, in yeast.The Journal of biological chemistry · 2013Article
- Positive roles for negative regulators in the mating response of yeast.Molecular systems biology · 2012Article
- The regulation of filamentous growth in yeast.Genetics · 2012Review
- Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast.The Journal of biological chemistry · 2011Article
- The homeodomain transcription factor Ste12: Connecting fungal MAPK signalling to plant pathogenicity.Communicative & integrative biology · 2010Article
- Ste12 and Ste12-like proteins, fungal transcription factors regulating development and pathogenicity.Eukaryotic cell · 2010Review
- Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast.PloS one · 2009Article
- Mechanisms and constraints on yeast MAPK signaling specificity.Biophysical journal · 2009Article
- Nucleus-specific and cell cycle-regulated degradation of mitogen-activated protein kinase scaffold protein Ste5 contributes to the control of signaling competence.Molecular and cellular biology · 2009Article
- Dose-to-duration encoding and signaling beyond saturation in intracellular signaling networks.PLoS computational biology · 2008Article
- The same receptor, G protein, and mitogen-activated protein kinase pathway activate different downstream regulators in the alternative white and opaque pheromone responses of Candida albicans.Molecular biology of the cell · 2008Article
- Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.Biochimica et biophysica acta · 2007Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The Ste12 transcription factor of Saccharomyces cerevisiae regulates transcription programs controlling two different developmental fates. One is differentiation into a mating-competent form that occurs in response to mating pheromone. The other is the transition to a filamentous-growth form that occurs in response to nutrient deprivation. These two distinct roles for Ste12 make it a focus for studies into regulatory mechanisms that impart biological specificity. The transient signal characteristic of mating differentiation led us to test the hypothesis that regulation of Ste12 turnover might contribute to attenuation of the mating-specific transcription program and restrict activation of the filamentation program. We show that prolonged pheromone induction leads to ubiquitin-mediated destabilization and decreased amounts of Ste12. This depletion in pheromone-stimulated cultures is dependent on the mating-pathway-dedicated mitogen-activated protein kinase Fus3 and its target Cdc28 inhibitor, Far1. Attenuation of pheromone-induced mating-specific gene transcription (FUS1) temporally correlates with Ste12 depletion. This attenuation is abrogated in the deletion backgrounds (fus3Delta or far1Delta) where Ste12 is found to persist. Additionally, pheromone induces haploid invasion and filamentous-like growth instead of mating differentiation when Ste12 levels remain high. These observations indicate that loss of Ste12 reinforces the adaptive response to pheromone and contributes to the curtailing of a filamentation response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.