ArticleApplied and environmental microbiology2006
Different levels of transcriptional regulation due to trophic constraints in the reduced genome of Buchnera aphidicola APS.
Article in Applied and environmental microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 90 citations in OpenAlex.
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- microRNA-92a regulates the expression of aphid bacteriocyte-specific secreted protein 1.BMC research notes · 2019Article
- Bacteriocyte Reprogramming to Cope With Nutritional Stress in a Phloem Sap Feeding Hemipteran, the Pea AphidFrontiers in physiology · 2018Article
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- Signatures of host/symbiont genome coevolution in insect nutritional endosymbioses.Proceedings of the National Academy of Sciences of the United States of America · 2015Review
- Widespread expression of conserved small RNAs in small symbiont genomes.The ISME journal · 2014Article
- Matching the supply of bacterial nutrients to the nutritional demand of the animal host.Proceedings. Biological sciences · 2014Article
- Aphid amino acid transporter regulates glutamine supply to intracellular bacterial symbionts.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Comparative analysis of genome sequences from four strains of the Buchnera aphidicola Mp endosymbion of the green peach aphid, Myzus persicae.BMC genomics · 2013Article
- Tyrosine pathway regulation is host-mediated in the pea aphid symbiosis during late embryonic and early larval development.BMC genomics · 2013Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Symbiotic associations involving intracellular microorganisms and animals are widespread, especially for species feeding on poor or unbalanced diets. Buchnera aphidicola, the obligate intracellular bacterium associated with most aphid species, provides its hosts with essential amino acids (EAAs), nutrients in short supply in the plant phloem sap. The Buchnera genome has undergone severe reductions during intracellular evolution. Genes for EAA biosynthesis are conserved, but most of the transcriptional regulatory elements are lost. This work addresses two main questions: is transcription in Buchnera (i) regulated and (ii) scaled to aphid EAA demand? Two microarray experiments were designed for profiling the gene expression in Buchnera. The first one was characterized by a specific depletion of tyrosine and phenylalanine in the aphid diet, and the second experiment combined a global diminution of EAAs in the aphid diet with a sucrose concentration increase to manipulate the aphid growth rate. Aphid biological performance and budget analysis (the balance between EAAs provided by the diet and those synthesized by Buchnera) were performed to quantify the nutritional demand from the aphids toward their symbiotic bacteria. Despite the absence of known regulatory elements, a significant transcriptional regulation was observed at different levels of organization in the Buchnera genome: between genes, within putative transcription units, and within specific metabolic pathways. However, unambiguous evidence for transcriptional changes underpinning the scaling of EAA biosynthesis to aphid demand was not obtained. The phenotypic relevance of the transcriptional response from the reduced genome of Buchnera is addressed.
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