ArticleThe Plant cell2006
Abiotic stress generates ROS that signal expression of anionic glutamate dehydrogenases to form glutamate for proline synthesis in tobacco and grapevine.
Article in The Plant cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 1 of them a synthesis that pooled it.
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150 citing papers in PubMed, 1 synthesis or guideline pooled it, 447 citations in OpenAlex.
- Transcriptome meta-analysis-based identification of hub transcription factors and RNA-binding proteins potentially orchestrating gene regulatory cascades and crosstalk in response to abiotic stresses in Arabidopsis thaliana.Journal of applied genetics · 2024Pooled it
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- Genome-wide identification of the GT transcription factor family in alfalfa and functional characterization of MsGT16 in salt stress tolerance.BMC genomics · 2026Article
- Integrated proteomic analysis reveals adaptation mechanisms of paper mulberry seedling leaves to nitrogen stress.BMC plant biology · 2026Article
- Ammonium assimilation inhibitors weaken the growth of moso bamboo seedlings through metabolic dysregulation.PeerJ · 2026Article
- NBPT improves root morphology and yield of cotton under salinity through changes in root nitrogen-metabolizing enzymes.Frontiers in plant science · 2026Article
- Interaction of 4-Aminobutyrate (GABA) with the Tricarboxylic Acid Cycle in Plants Under Salinity Stress.Plants (Basel, Switzerland) · 2026Review
- The role of alternative oxidase in the maintenance of cellular redox balance under hypoxia via participation in nitric oxide turnover.Journal of experimental botany · 2025Review
- Gamma-Aminobutyric Acid: A Novel Biomolecule to Improve Plant Resistance and Fruit Quality.Plants (Basel, Switzerland) · 2025Review
- Integrated analysis of metabolites and enzyme activities reveals the plasticity of central carbon metabolism in grape (Horticulture research · 2025Article
- Integration of metabolic and transcriptomic analyses for revealing the galactose metabolism of tobacco (Frontiers in plant science · 2025Article
- The Nitrogen Preference of Cactus Pear (Plants (Basel, Switzerland) · 2024Article
- Natural variation in the adjustment of primary metabolism determines ammonium tolerance in the model grass Brachypodium distachyon.Journal of experimental botany · 2024Article
- FERONIA regulates salt tolerance in Arabidopsis by controlling photorespiratory flux.The Plant cell · 2024Article
- Biochemical and Epigenetic Regulation of Glutamate Metabolism in Maize (Plants (Basel, Switzerland) · 2024Article
- Disruption of Poly(ADP-ribosyl)ation Improves Plant Tolerance to Methyl Viologen-Mediated Oxidative Stress via Induction of ROS Scavenging Enzymes.International journal of molecular sciences · 2024Article
- Unraveling the Role of the Liriodendron Thioredoxin (TRX) Gene Family in an Abiotic Stress Response.Plants (Basel, Switzerland) · 2024Article
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- Metabolomic Response ofPlants (Basel, Switzerland) · 2024Article
- Physiological response to low-nitrogen stress and comprehensive evaluation in four rice varieties.Photosynthetica · 2024Article
90 more citing papers are in PubMed but not listed here.
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10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate dehydrogenase (GDH) may be a stress-responsive enzyme, as GDH exhibits considerable thermal stability, and de novo synthesis of the alpha-GDH subunit is induced by exogenous ammonium and senescence. NaCl treatment induces reactive oxygen species (ROS), intracellular ammonia, expression of tobacco (Nicotiana tabacum cv Xanthi) gdh-NAD;A1 encoding the alpha-subunit of GDH, increase in immunoreactive alpha-polypeptide, assembly of the anionic isoenzymes, and in vitro GDH aminating activity in tissues from hypergeous plant organs. In vivo aminating GDH activity was confirmed by gas chromatorgraphy-mass spectrometry monitoring of (15)N-Glu, (15)N-Gln, and (15)N-Pro in the presence of methionine sulfoximine and amino oxyacetic acid, inhibitors of Gln synthetase and transaminases, respectively. Along with upregulation of alpha-GDH by NaCl, isocitrate dehydrogenase genes, which provide 2-oxoglutarate, are also induced. Treatment with menadione also elicits a severalfold increase in ROS and immunoreactive alpha-polypeptide and GDH activity. This suggests that ROS participate in the signaling pathway for GDH expression and protease activation, which contribute to intracellular hyperammonia. Ammonium ions also mimic the effects of salinity in induction of gdh-NAD;A1 expression. These results, confirmed in tobacco and grape (Vitis vinifera cv Sultanina) tissues, support the hypothesis that the salinity-generated ROS signal induces alpha-GDH subunit expression, and the anionic iso-GDHs assimilate ammonia, acting as antistress enzymes in ammonia detoxification and production of Glu for Pro synthesis.
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