ReviewClinical microbiology reviews2006
Updated review of blood culture contamination.
Review in Clinical microbiology reviews, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 352 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
352 citing papers in PubMed, 1 synthesis or guideline pooled it, 867 citations in OpenAlex.
- American Society for Microbiology evidence-based laboratory medicine practice guidelines to reduce blood culture contamination rates: a systematic review and meta-analysis.Clinical microbiology reviews · 2024Pooled it
- An overview of positive cultures and clinical outcomes in septic patients: a sub-analysis of the Prehospital Antibiotics Against Sepsis (PHANTASi) trial.Critical care (London, England) · 2019Trial
- Clinical outcomes of teicoplanin for Corynebacterium species bacteremia: A retrospective observational study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Microbial signal profiles and organism-level concordance between plasma metagenomic sequencing and blood culture in suspected bloodstream infection.World journal of microbiology & biotechnology · 2026Article
- Variability in Hospital-Onset Bacteremia in Ontario.JAMA network open · 2026Article
- Diagnosing Sepsis and Identifying Bacterial Resistance Genes Directly from Whole Blood Using a Rapid Real-Time PCR System.International journal of molecular sciences · 2026Article
- Bacterial bloodstream infections in pediatric oncology patients in a tertiary medical center: pathogen distribution, antimicrobial nonsusceptibility, and outcomes.European journal of pediatrics · 2026Article
- Clinical Features and 1-Year Prognosis of Patients with Suspected Sepsis and Positive Blood Cultures in the Emergency Department: A Single-Center Retrospective Study.Medicina (Kaunas, Lithuania) · 2026Article
- Clinical, Laboratory, Infectious, and Intervention Factors Associated with ICU Mortality: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Four-day versus five-day blood culture incubation: a prospective study of diagnostic performance using the bioMérieux BACT/ALERT VIRTUO system.BMC infectious diseases · 2026Article
- Predictors and Clinical Impact of Positive Blood Cultures in Emergency Department Patients with Suspected Infection.Medicina (Kaunas, Lithuania) · 2026Article
- Low-Value Blood Culture Use in Adult Emergency Department Patients: A Scoping Review.Emergency medicine Australasia : EMA · 2026Article
- Evaluating the Cost Effectiveness of Rapid Diagnostic Testing for the Identification of Pathogens and Resistance Genes in Bloodstream Infections.PharmacoEconomics · 2026Article
- PolymicrobialJournal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2026Article
- Comparative Effectiveness of Azithromycin Versus Doxycycline in Hospitalized Patients With Community-Acquired Pneumonia Treated With Beta-Lactams: A Multicenter Matched Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Development and validation of a bacteremia prediction score for adult emergency department patients using hybrid machine learning and regression.Scientific reports · 2026Article
- Impact of switching from manual to automated aerobic blood culture on bacteremia diagnosis in Lao PDR.Microbiology spectrum · 2026Article
- Diagnostic disruption during a blood culture bottle shortage: clinical and laboratory adaptation strategies.Microbiology spectrum · 2026Observational
- Pathogen characteristics are key determinants of distinct host response phenotypes of sepsis.The Journal of clinical investigation · 2026Observational
- Derivation and validation of a new prediction score for bacteremia in the emergency department.Scientific reports · 2026Article
292 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood culture contamination represents an ongoing source of frustration for clinicians and microbiologists alike. Ambiguous culture results often lead to diagnostic uncertainty in clinical management and are associated with increased health care costs due to unnecessary treatment and testing. A variety of strategies have been investigated and employed to decrease contamination rates. In addition, numerous approaches to increase our ability to distinguish between clinically significant bacteremia and contamination have been explored. In recent years, there has been an increase in the application of computer-based tools to support infection control activities as well as provide clinical decision support related to the management of infectious diseases. Finally, new approaches for estimating bacteremia risk which have the potential to decrease unnecessary blood culture utilization have been developed and evaluated. In this review, we provide an overview of blood culture contamination and describe the potential utility of a variety of approaches to improve both detection and prevention. While it is clear that progress is being made, fundamental challenges remain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.