ArticleJournal of bacteriology2007
Complete sequence analysis of novel plasmids from emetic and periodontal Bacillus cereus isolates reveals a common evolutionary history among the B. cereus-group plasmids, including Bacillus anthracis pXO1.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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65 citing papers in PubMed, 156 citations in OpenAlex.
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- Pathogenicity and Genomic Characterization of a Novel Genospecies,International journal of molecular sciences · 2023Article
- The influence of extrachromosomal elements in the anthrax "cross-over" strainFrontiers in microbiology · 2023Article
- Retrospective surveillance of viableFrontiers in microbiology · 2023Article
- Impact of a Novel PagR-like Transcriptional Regulator on Cereulide Toxin Synthesis in EmeticInternational journal of molecular sciences · 2022Article
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- Adaptation of Bacillus thuringiensis to Plant Colonization Affects Differentiation and Toxicity.mSystems · 2021Article
- Genetic diversity and the presence of circular plasmids in Bacillus cereus isolates of clinical and environmental origin.Archives of microbiology · 2021Article
- Structure Revision of Isocereulide A, an Isoform of the Food Poisoning EmeticMolecules (Basel, Switzerland) · 2021Article
- The Food Poisoning Toxins ofToxins · 2021Review
- Identification of a New Pathogenicity Island Within the Large pAH187_270 Plasmid Involved inFrontiers in cellular and infection microbiology · 2021Article
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- Phylogenetic Analysis ofMicroorganisms · 2020Article
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- Identification of A Novel Arsenic Resistance Transposon Nested in A Mercury Resistance Transposon ofMicroorganisms · 2019Article
- TheMicrobiology spectrum · 2019Review
5 more citing papers are in PubMed but not listed here.
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9 authors at 1 institution in 1 country.
Funding
Abstract
The plasmids of the members of the Bacillus cereus sensu lato group of organisms are essential in defining the phenotypic traits associated with pathogenesis and ecology. For example, Bacillus anthracis contains two plasmids, pXO1 and pXO2, encoding toxin production and encapsulation, respectively, that define this species pathogenic potential, whereas the presence of a Bt toxin-encoding plasmid defines Bacillus thuringiensis isolates. In this study the plasmids from B. cereus isolates that produce emetic toxin or are linked to periodontal disease were sequenced and analyzed. Two periodontal isolates examined contained almost identical approximately 272-kb plasmids, named pPER272. The emetic toxin-producing isolate contained one approximately 270-kb plasmid, named pCER270, encoding the cereulide biosynthesis gene cluster. Comparative sequence analyses of these B. cereus plasmids revealed a high degree of sequence similarity to the B. anthracis pXO1 plasmid, especially in a putative replication region. These plasmids form a newly defined group of pXO1-like plasmids. However, these novel plasmids do not contain the pXO1 pathogenicity island, which in each instance is replaced by plasmid specific DNA. Plasmids pCER270 and pPER272 share regions that are not found in any other pXO1-like plasmids. Evolutionary studies suggest that these plasmids are more closely related to each other than to other identified B. cereus plasmids. Screening of a population of B. cereus group isolates revealed that pXO1-like plasmids are more often found in association with clinical isolates. This study demonstrates that the pXO1-like plasmids may define pathogenic B. cereus isolates in the same way that pXO1 and pXO2 define the B. anthracis species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.