ArticleJournal of bacteriology2006
Characterization of a highly conserved island in the otherwise divergent Bordetella holmesii and Bordetella pertussis genomes.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Emergence of Bordetella holmesii-Associated Pertussis-Like Illness, Northern India, 2019-2023.Emerging infectious diseases · 2025Article
- Article
- Article
- Bordetella holmesii: Lipid A Structures and Corresponding Genomic Sequences Comparison in Three Clinical Isolates and the Reference Strain ATCC 51541.International journal of molecular sciences · 2017Article
- Epidemiology of pertussis in Casablanca (Morocco): contribution of conventional and molecular diagnosis tools.BMC infectious diseases · 2017Article
- Acquisition and loss of virulence-associated factors during genome evolution and speciation in three clades of Bordetella species.BMC genomics · 2016Article
- Laboratory Diagnosis of Pertussis.Clinical microbiology reviews · 2015Review
- Genome Sequences of Nine Bordetella holmesii Strains Isolated in the United States.Genome announcements · 2014Article
- Bordetella holmesii: initial genomic analysis of an emerging opportunist.Pathogens and disease · 2013Article
- Insertion sequences shared by Bordetella species and implications for the biological diagnosis of pertussis syndrome.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013Article
- Lack of cross-protection against Bordetella holmesii after pertussis vaccination.Emerging infectious diseases · 2012Article
- Comparative genomics of the classical Bordetella subspecies: the evolution and exchange of virulence-associated diversity amongst closely related pathogens.BMC genomics · 2012Article
- First report of infectious pericarditis due to Bordetella holmesii in an adult patient with malignant lymphoma.Journal of clinical microbiology · 2012Article
- Bordetella petrii infection with long-lasting persistence in human.Emerging infectious diseases · 2011Article
- Article
- Resemblance and divergence: the "new" members of the genus Bordetella.Medical microbiology and immunology · 2010Review
- Genomic island excisions in Bordetella petrii.BMC microbiology · 2009Article
- Identification and regulation of expression of a gene encoding a filamentous hemagglutinin-related protein in Bordetella holmesii.BMC microbiology · 2007Article
- Impact of alcaligin siderophore utilization on in vivo growth of Bordetella pertussis.Infection and immunity · 2007Article
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Authors and funding
7 authors.
Funding
Abstract
The recently discovered pathogen Bordetella holmesii has been isolated from the airways and blood of diseased humans. Genetic events contributing to the emergence of B. holmesii are not understood, and its phylogenetic position among the bordetellae remains unclear. To address these questions, B. holmesii strains were analyzed by comparative genomic hybridization (CGH) to a Bordetella pertussis microarray and by multilocus sequence typing. Both methods indicated substantial sequence divergence between B. pertussis and B. holmesii. However, CGH identified a putative pathogenicity island of 66 kb that is highly conserved between these species and contains several IS481 elements that may have been laterally transferred from B. pertussis to B. holmesii. This island contains, among other genes, a functional, iron-regulated locus encoding the biosynthesis, export, and uptake of the siderophore alcaligin. The acquisition of this genomic island by B. holmesii may have significantly contributed to its emergence as a human pathogen. Horizontal gene transfer between B. pertussis and B. holmesii may also explain the unusually high sequence identity of their 16S rRNA genes.
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