SynthesisThorax2007
Outcome of occupational asthma after cessation of exposure: a systematic review.
Synthesis in Thorax, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Contribution of host factors and workplace exposure to the outcome of occupational asthma.European respiratory review : an official journal of the European Respiratory Society · 2012Pooled it
- What is the optimal management option for occupational asthma?European respiratory review : an official journal of the European Respiratory Society · 2012Pooled it
- Work-Related Asthma: An Occupational Medicine Perspective.Allergy, asthma & immunology research · 2026Review
- Review
- Occupational Respiratory Allergy to Flour in the Modern Era.Current allergy and asthma reports · 2025Review
- Effects of Interventions to Prevent Work-Related Asthma, Allergy, and Other Hypersensitivity Reactions in Norwegian Salmon Industry Workers (SHInE): Protocol for a Pragmatic Allocated Intervention Trial and Related Substudies.JMIR research protocols · 2023Article
- Occupational Asthma: The Knowledge Needs for a Better Management.Annals of work exposures and health · 2022Article
- Occupational use of high-level disinfectants and asthma incidence in early- to mid-career female nurses: a prospective cohort study.Occupational and environmental medicine · 2021Article
- Causes and Phenotypes of Work-Related Asthma.International journal of environmental research and public health · 2020Review
- Progress in Occupational Asthma.International journal of environmental research and public health · 2020Review
- Workplace interventions for treatment of occupational asthma.The Cochrane database of systematic reviews · 2019Review
- Update on the Management of Occupational Asthma and Work-Exacerbated Asthma.Allergy, asthma & immunology research · 2019Review
- Medical surveillance and long-term prognosis of occupational allergy due to platinum salts.International archives of occupational and environmental health · 2017Observational
- Do Low Molecular Weight Agents Cause More Severe Asthma than High Molecular Weight Agents?PloS one · 2016Article
- An official American Thoracic Society Workshop Report: presentations and discussion of the fifth Jack Pepys Workshop on Asthma in the Workplace. Comparisons between asthma in the workplace and non-work-related asthma.Annals of the American Thoracic Society · 2015Article
- Prevalence of Work-Related Asthma in Primary Health Care: Study Rationale and Design.The open respiratory medicine journal · 2015Article
- Human mesenchymal stem cells resolve airway inflammation, hyperreactivity, and histopathology in a mouse model of occupational asthma.Stem cells and development · 2014Article
- Performing a lung disability evaluation: how, when, and why?Journal of occupational and environmental medicine · 2014Review
- Diisocyanate-induced asthma in Switzerland: long-term course and patients' self-assessment after a 12-year follow-up.Journal of occupational medicine and toxicology (London, England) · 2014Article
- Work-related asthma and employment status--38 states and District of Columbia, 2006-2009.The Journal of asthma : official journal of the Association for the Care of Asthma · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with occupational asthma, and their medical advisers, need valid information about the prognosis of their disease.
methodsA systematic review of the published literature on the symptomatic and functional outcomes of occupational asthma was carried out after avoidance of exposure to the causative agent. Through a full search of electronic and bibliographic sources, original studies documenting complete recovery from asthma (n = 39,1681 patients) or improvement in non-specific bronchial hyper-responsiveness (NSBHR; n = 28,695 patients) were identified. The median duration of follow-up was 31 (range 6-240) months for studies of symptomatic recovery and 37 (6-240) months for studies of NSBHR. Most studies were of patients recruited from special clinics.
resultsReported rates of symptomatic recovery varied from 0% to 100%, with a pooled estimate of 32% (95% CI 26% to 38%). These rates were lower with increasing age (p = 0.019) and among clinic based populations (p = 0.053). Patients with the shortest durations of exposure (< or =76 months) had the highest rate of recovery (36%; 95% CI 25% to 50%), but the effect was not linear. The pooled prevalence of persistent NSBHR at follow-up was 73% (95% CI 66% to 79%). This figure was higher among patients whose disease was due to high-molecular-weight agents (p = 0.006) and, less clearly, those from clinic-based populations (p = 0.561). In between-study comparisons, no clear patterns of improvement relating to total duration of exposure or follow-up were found. From within-study comparisons there was some evidence that a shorter duration of symptoms was associated with a higher rate of symptomatic recovery.
conclusionThe available data on the prognosis of occupational asthma are insufficiently consistent to allow confident advice to be given to patients with the disease. Clinicians and epidemiologists with an interest in this disease should consider a collaborative and carefully standardised study of the prognosis of occupational asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.