ReviewMayo Clinic proceedings2006
Extreme obesity: a new medical crisis in the United States.
Review in Mayo Clinic proceedings, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00941382 (Double-blind, Randomized Clinical Trial to Evaluate Effect of Combination Therapy of Metformin and Sibutramine Versus Metformin or Sibutramine Monotherapy Over Weight, Adiposity, Glucose Metabolism and Inflammatory State in Obese Patients), which is not on this map. Cited by 65 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Double-blind, Randomized Clinical Trial to Evaluate Effect of Combination Therapy of Metformin and Sibutramine Versus Metformin or Sibutramine Monotherapy Over Weight, Adiposity, Glucose Metabolism and Inflammatory State in Obese Patients
Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bariatric surgery: a systematic review of the clinical and economic evidence.Journal of general internal medicine · 2011Pooled it
- Investigation of the 1-week effect of traffic light nutrition labeling on diet selection among Japanese university students: a randomized controlled trial.BMC public health · 2024Trial
- The evaluating self-management and educational support in severely obese patients awaiting multidisciplinary bariatric care (EVOLUTION) trial: rationale and design.BMC health services research · 2013Trial
- A rapid beverage intake questionnaire can detect changes in beverage intake.Eating behaviors · 2013Trial
- Empiric auto-titrating CPAP in people with suspected obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2010Trial
- Disproportionate increase of extreme obesity among older adults: an exploratory analysis from the English longitudinal study of ageing.Aging clinical and experimental research · 2026Article
- Article
- Normalisation of AHI Under Positive Pressure Therapy Does Not Necessarily Mean Control of Symptoms: A Comparison of the Effectiveness of APAP and CPAP on Daytime Sleepiness and Nocturnal Urination.Life (Basel, Switzerland) · 2025Article
- 2023 Obesity Fact Sheet: Prevalence of Obesity and Abdominal Obesity in Adults, Adolescents, and Children in Korea from 2012 to 2021.Journal of obesity & metabolic syndrome · 2024Article
- Oocyte Aging: A Multifactorial Phenomenon in A Unique Cell.Aging and disease · 2024Review
- Attenuation of palmitic acid-induced lysyl oxidase overexpression in the ovary contributes to the improvement of ovulation in obesity by metformin.Human reproduction open · 2024Article
- Using dialogue-centered approaches to community-engaged research: an application of dialectical inquiry.Discover global society · 2024Article
- Mendelian randomization supports causality between overweight status and accelerated aging.Aging cell · 2023Article
- Relationship between obesity-related colorectal tumors and the intestinal microbiome: an animal-based trial.Journal of cancer research and clinical oncology · 2023Article
- The role of traditional obesity parameters in predicting the number of stenosed coronary arteries (≥ 60%) among patients undergoing cardiac catheterization.Scientific reports · 2022Article
- Association of Overweight and Consistent Anovulation among Infertile Women with Regular Menstrual Cycle: A Case-control Study.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2021Article
- Article
- Safety and Efficacy of Moderate Sedation in Super Obese Patients Undergoing Lower and Upper GI Endoscopy: a Case-Control Study.Obesity surgery · 2020Article
- An Atypical Case of Morbid Obesity, Presenting With Deep Vein Thrombosis and Pulmonary Embolism.Cureus · 2020Article
- Effectiveness and Characterization of Severely Energy-Restricted Diets in People with Class III Obesity: Systematic Review and Meta-Analysis.Behavioral sciences (Basel, Switzerland) · 2019Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of obesity has markedly increased in the past few decades, and this disorder is responsible for more health care expenditures than any other medical condition. The greater the body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters), the greater the risk of comorbidities, including diabetes mellitus, hypertension, obstructive sleep apnea, many cancers, dyslipidemia, cardiovascular disease, and overall mortality. Class III (extreme) obesity, defined as a BMI of 40 kg/m2 or greater, has also increased such that it now affects almost 1 in 20 Americans. The prevalence of extreme obesity is greater among women than among men and greater among blacks than among non-Hispanic whites or Hispanics. The effect of extreme obesity on mortality is greater among young than among older adults, greater among men than among women, and greater among whites than among blacks. The current permissive environment that promotes increased dietary energy intake and decreased energy expenditure through reduced daily physical activity coupled with genetic susceptibility is an important pathogenic factor. The number of bariatric surgical procedures performed annually is relatively small but increasing.
Indexed as
Identifiers
17036573What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.