ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Dopaminergic control of sleep-wake states.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
137 citing papers in PubMed, 1 synthesis or guideline pooled it, 319 citations in OpenAlex.
- Digital sleep phenotype and wrist actigraphy in individuals at clinical high risk for psychosis and people with schizophrenia spectrum disorders: a systematic review and meta-analysis.BMJ mental health · 2025Pooled it
- Trial
- Sustained Modafinil Treatment Effects on Control-Related Gamma Oscillatory Power in Schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory.Sleep · 2012Trial
- Sleep Health and Quality of Life in Children and Adolescents with NF1: A Biopsychosocial Perspective.Cancers · 2026Article
- Sleep-circadian modulation of autophagy and glymphatic function: failure of coordinated brain clearance in Parkinson's disease.NPJ Parkinson's disease · 2026Review
- Restorative or Disruptive? Effects of Antidepressants on Sleep Architecture in Depression.CNS drugs · 2026Review
- Article
- Sleep regulates drug seeking and relapse - a perspective.Molecular psychiatry · 2026Review
- Role of neural oscillations in depression: highlights on gamma oscillations.Translational psychiatry · 2026Review
- Gut-initiated alpha synuclein fibrils drive parkinsonism phenotypes: temporal mapping of REM sleep behavior disorder-like and other non-motor symptoms.Translational neurodegeneration · 2026Article
- Longan flower water extract promotes sleep in mice via the serotonin-melatonin axis.Journal of the science of food and agriculture · 2026Article
- IL-1b and TNF-a-driven sleep alterations: Neuroimmune mechanisms and behavioral implications.Brain, behavior, & immunity - health · 2025Review
- Article
- Differential Modulation of Dopamine D2 Receptor on Somatostatin and Parvalbumin Interneurons in the CA1 Area of the Dorsal Hippocampus.The European journal of neuroscience · 2025Article
- TAAR8 in the Brain: Implications for Dopaminergic Function, Neurogenesis, and Behavior.Biomedicines · 2025Article
- Pregnant women's sleep quality and its associated factors among antenatal care attendants in Bahir Dar City, Northwest Ethiopia.Scientific reports · 2025Article
- Impact of ischemic lesion on sleep related connectivity in the sensorimotor cortex.Frontiers in neuroscience · 2025Article
- Sleep-Related Eating Disorder and Sexsomnia; Two Rare Parasomnias? A Mini-Review with Illustrative Case-Reports.International journal of sexual health : official journal of the World Association for Sexual Health · 2025Article
- Dopamine D2 receptor modulating mPFC-BLA circuit contributes to chronic sleep deprivation-induced memory impairment in mice.Theranostics · 2025Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopamine depletion is involved in the pathophysiology of Parkinson's disease, whereas hyperdopaminergia may play a fundamental role in generating endophenotypes associated with schizophrenia. Sleep disturbances are known to occur in both schizophrenia and Parkinson's disease, suggesting that dopamine plays a role in regulating the sleep-wake cycle. Here, we show that novelty-exposed hyperdopaminergic mice enter a novel awake state characterized by spectral patterns of hippocampal local field potentials that resemble electrophysiological activity observed during rapid-eye-movement (REM) sleep. Treatment with haloperidol, a D2 dopamine receptor antagonist, reduces this abnormal intrusion of REM-like activity during wakefulness. Conversely, mice acutely depleted of dopamine enter a different novel awake state characterized by spectral patterns of hippocampal local field potentials that resemble electrophysiological activity observed during slow-wave sleep (SWS). This dopamine-depleted state is marked by an apparent suppression of SWS and a complete suppression of REM sleep. Treatment with D2 (but not D1) dopamine receptor agonists recovers REM sleep in these mice. Altogether, these results indicate that dopamine regulates the generation of sleep-wake states. We propose that psychosis and the sleep disturbances experienced by Parkinsonian patients result from dopamine-mediated disturbances of REM sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.