ArticleProceedings of the National Academy of Sciences of the United States of America2006
IL-1 resets glucose homeostasis at central levels.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 78 citations in OpenAlex.
- Ketone bodies mitigate against systemic inflammation-induced changes in brain energy metabolism and delirium-like deficits in aged mice.bioRxiv : the preprint server for biology · 2026Article
- Eye on the horizon: The metabolic landscape of the RPE in aging and disease.Progress in retinal and eye research · 2025Review
- Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance.Cell metabolism · 2023Article
- Hepatic interleukin-1 receptor type 1 signalling regulates insulin sensitivity in the early phases of nonalcoholic fatty liver disease.Clinical and translational medicine · 2022Article
- Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion.Molecular metabolism · 2022Article
- [The role of cytokines in the processes of adaptive integration of immune and neuroendocrine reactions of the human body].Problemy endokrinologii · 2021Article
- Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Hypoglycemia After Upper Gastrointestinal Surgery: Clinical Approach to Assessment, Diagnosis, and Treatment.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Hypoglycemia-activated Hypothalamic Microglia Impairs Glucose Counterregulatory Responses.Scientific reports · 2019Article
- Exploring pancreatic pathology in Plasmodium falciparum malaria patients.Scientific reports · 2018Article
- Hexokinase 2 and nuclear factor erythroid 2-related factor 2 transcriptionally coactivate xanthine oxidoreductase expression in stressed glioma cells.The Journal of biological chemistry · 2018Article
- The islet-resident macrophage is in an inflammatory state and senses microbial products in blood.The Journal of experimental medicine · 2017Article
- Glucose and insulin modulate sickness responses in male Siberian hamsters.General and comparative endocrinology · 2017Article
- Cerebral ischemic damage in diabetes: an inflammatory perspective.Journal of neuroinflammation · 2017Review
- Brain-borne IL-1 adjusts glucoregulation and provides fuel support to astrocytes and neurons in an autocrine/paracrine manner.Molecular psychiatry · 2016Article
- Non-ICU hospital care of diabetes mellitus in the elderly population.Current diabetes reports · 2015Review
- Inpatient hypoglycemia: a challenge that must be addressed.Current diabetes reports · 2014Article
- A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome.Metabolic brain disease · 2013Review
- Reciprocal influences between leptin and glucocorticoids during acute Trypanosoma cruzi infection.Medical microbiology and immunology · 2013Article
- Hypoglycemia: The neglected complication.Indian journal of endocrinology and metabolism · 2013Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Administration of IL-1beta results in a profound and long-lasting hypoglycemia. Here, we show that this effect can be elicited by endogenous IL-1 and is related to not only the capacity of the cytokine to increase glucose uptake in peripheral tissues but also to mechanisms integrated in the brain. We show that (i) blockade of IL-1 receptors in the brain partially counteracted IL-1-induced hypoglycemia; (ii) peripheral administration or induction of IL-1 production resulted in IL-1beta gene expression in the hypothalamus of normal and insulin-resistant, leptin receptor-deficient, diabetic db/db mice; (iii) IL-1-treated normal and db/db mice challenged with glucose did not return to their initial glucose levels but remained hypoglycemic for several hours. This effect was largely antagonized by blockade of IL-1 receptors in the brain; and (iv) when animals with an advanced Type II diabetes were treated with IL-1 and challenged with glucose, they died in hypoglycemia. However, when IL-1 receptors in the brains of these diabetic mice were blocked, they survived, and glucose blood levels approached those that these mice had before IL-1 administration. The prolonged hypoglycemic effect of IL-1 is insulin-independent and develops against increased levels of glucocorticoids, catecholamines, and glucagon. These findings, together with the present demonstration that this effect is integrated in the brain and is paralleled by IL-1beta expression in the hypothalamus, indicate that this cytokine can reset glucose homeostasis at central levels. Such reset, along with the peripheral actions of the cytokine, would favor glucose uptake by immune cells during inflammatory/immune processes.
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