ArticleThe Journal of cell biology1990
Structure and expression of genes for a class of cysteine-rich proteins of the cuticle layers of differentiating wool and hair follicles.
Article in The Journal of cell biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 70 citations in OpenAlex.
- Wool: From Properties and Structure to Genetic Insights and Sheep Improvement Strategies.Animals : an open access journal from MDPI · 2025Review
- Genetics of Wool and Cashmere Fibre: Progress, Challenges, and Future Research.Animals : an open access journal from MDPI · 2024Article
- The Complexity of the Ovine and Caprine Keratin-Associated Protein Genes.International journal of molecular sciences · 2021Review
- Protein-Based Fiber Materials in Medicine: A Review.Nanomaterials (Basel, Switzerland) · 2018Review
- Review
- Hair for brain trade-off, a metabolic bypass for encephalization.SpringerPlus · 2014Article
- An updated nomenclature for keratin-associated proteins (KAPs).International journal of biological sciences · 2012Review
- Location of Keratin-associated Proteins in Developing Fiber Cuticle Cells using Immunoelectron Microscopy.International journal of trichology · 2010Article
- Comparative genomics of the keratin-associated protein (KAP) gene clusters in human, chimpanzee, and baboon.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Expression of a wool intermediate filament keratin transgene in sheep fibre alters structure.Transgenic research · 1998Article
- The genetic engineering of production traits in domestic animals.Experientia · 1991Review
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1991Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major histological components of the hair follicle are the hair cortex and cuticle. The hair cuticle cells encase and protect the cortex and undergo a different developmental program to that of the cortex. We report the molecular characterization of a set of evolutionarily conserved hair genes which are transcribed in the hair cuticle late in follicle development. Two genes were isolated and characterized, one expressed in the human follicle and one in the sheep follicle. Each gene encodes a small protein of 16 kD, containing greater than 50 cysteine residues, ranging from 31 to 36 mol% cysteine. Their high cysteine content and in vitro expression data identify them as ultra-high-sulfur (UHS) keratin proteins. The predicted proteins are composed almost entirely of cysteine-rich and glycine-rich repeats. Genomic blots reveal that the UHS keratin proteins are encoded by related multigene families in both the human and sheep genomes. Tissue in situ hybridization demonstrates that the expression of both genes is localized to the hair fiber cuticle and occurs at a late stage in fiber morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.