ArticleJournal of neurophysiology2007
Complementary postsynaptic activity patterns elicited in olfactory bulb by stimulation of mitral/tufted and centrifugal fiber inputs to granule cells.
Article in Journal of neurophysiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Essential Role of the Anterior Piriform Cortex in Mediating Social Novelty Output via a Top-Down Circuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Endocannabinoid-mediated neuromodulation in the main olfactory bulb at the interface of environmental stimuli and central neural processing.The European journal of neuroscience · 2022Review
- Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia.International journal of molecular sciences · 2021Review
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- Cannabinoids Regulate Sensory Processing in Early Olfactory and Visual Neural Circuits.Frontiers in neural circuits · 2021Review
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- POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Cannabinoid Receptors Modulate Excitation of an Olfactory Bulb Local Circuit by Cortical Feedback.Frontiers in cellular neuroscience · 2018Article
- Developmental broadening of inhibitory sensory maps.Nature neuroscience · 2017Article
- Oxytocin Enhances Social Recognition by Modulating Cortical Control of Early Olfactory Processing.Neuron · 2016Article
- Spatio-Temporal Characteristics of Inhibition Mapped by Optical Stimulation in Mouse Olfactory Bulb.Frontiers in neural circuits · 2016Article
- Layer-Specific fMRI Responses to Excitatory and Inhibitory Neuronal Activities in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- BDNF over-expression increases olfactory bulb granule cell dendritic spine density in vivo.Neuroscience · 2015Article
- Allosteric Modulation of GABAA Receptors by an Anilino Enaminone in an Olfactory Center of the Mouse Brain.Pharmaceuticals (Basel, Switzerland) · 2014Review
- Long-term plasticity in the regulation of olfactory bulb activity by centrifugal fibers from piriform cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Electrical responses of three classes of granule cells of the olfactory bulb to synaptic inputs in different dendritic locations.Frontiers in computational neuroscience · 2014Article
- Presynaptic inhibition of olfactory sensory neurons: new mechanisms and potential functions.Chemical senses · 2013Review
- NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Respiration drives network activity and modulates synaptic and circuit processing of lateral inhibition in the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Dynamic development of the first synapse impinging on adult-born neurons in the olfactory bulb circuit.Neural systems & circuits · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Main olfactory bulb (MOB) granule cells receive spatially segregated glutamatergic synaptic inputs from the dendrites of mitral/tufted cells as well as from the axons of centrifugal fibers (CFFs) originating in olfactory cortical areas. Dendrodendritic synapses from mitral/tufted cells occur on granule cell distal dendrites in the external plexiform layer (EPL), whereas CFFs preferentially target the somata/proximal dendrites of granule cells in the granule cell layer (GCL). In the present study, tract tracing, and recordings of field potentials and voltage-sensitive dye optical signals were used to map activity patterns elicited by activation of these two inputs to granule cells in mouse olfactory bulb slices. Stimulation of the lateral olfactory tract (LOT) produced a negative field potential in the EPL and a positivity in the GCL. CFF stimulation produced field potentials of opposite polarity in the EPL and GCL to those elicited by LOT. LOT-evoked optical signals appeared in the EPL and spread subsequently to deeper layers, whereas CFF-evoked responses appeared in the GCL and then spread superficially. Evoked responses were reduced by N-methyl-d-aspartate (NMDA) receptor antagonists and completely suppressed by AMPA receptor antagonists. Reduction of extracellular Mg(2+) enhanced the strength and spatiotemporal extent of the evoked responses. These and additional findings indicate that LOT- and CFF-evoked field potentials and optical signals reflect postsynaptic activity in granule cells, with moderate NMDA and dominant AMPA receptor components. Taken together, these results demonstrate that LOT and CFF stimulation in MOB slices selectively activate glutamatergic inputs to the distal dendrites versus somata/proximal dendrites of granule cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.