ArticleJournal of virology2006
The betaretrovirus Mason-Pfizer monkey virus selectively excludes simian APOBEC3G from virion particles.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Analysis of Simian Endogenous Retrovirus (SERV) Full-Length Proviruses in Old World Monkey Genomes.Genes · 2022Article
- The Role of APOBECs in Viral Replication.Microorganisms · 2020Review
- A high rate of polymerization during synthesis of mouse mammary tumor virus DNA alleviates hypermutation by APOBEC3 proteins.PLoS pathogens · 2019Article
- APOBECs and virus restriction.Virology · 2015Review
- Simian retrovirus 4 induces lethal acute thrombocytopenia in Japanese macaques.Journal of virology · 2015Article
- Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Endogenous MOV10 inhibits the retrotransposition of endogenous retroelements but not the replication of exogenous retroviruses.Retrovirology · 2012Article
- Retroelements versus APOBEC3 family members: No great escape from the magnificent seven.Frontiers in microbiology · 2012Article
- The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F.Journal of virology · 2010Article
- Long-term restriction by APOBEC3F selects human immunodeficiency virus type 1 variants with restored Vif function.Journal of virology · 2010Article
- Apobec 3G efficiently reduces infectivity of the human exogenous gammaretrovirus XMRV.PloS one · 2010Article
- Optimal translation initiation enables Vif-deficient human immunodeficiency virus type 1 to escape restriction by APOBEC3G.Journal of virology · 2009Article
- Are viruses inhibited by APOBEC3 molecules from their host species?PLoS pathogens · 2009Article
- APOBEC3G: an intracellular centurion.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- APOBEC proteins and intrinsic resistance to HIV-1 infection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin.Journal of virology · 2009Article
- Equine infectious anemia virus resists the antiretroviral activity of equine APOBEC3 proteins through a packaging-independent mechanism.Journal of virology · 2008Article
- The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals.BMC molecular biology · 2008Article
- Evolution of HIV-1 isolates that use a novel Vif-independent mechanism to resist restriction by human APOBEC3G.Current biology : CB · 2008Article
- Single-stranded RNA facilitates nucleocapsid: APOBEC3G complex formation.RNA (New York, N.Y.) · 2008Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
The APOBEC3 protein family can constitute a potent barrier to the successful infection of mammalian species by retroviruses. Therefore, any retrovirus that has evolved the ability to replicate in a given animal must have developed mechanisms that allow it to avoid or inhibit the APOBEC3 proteins expressed in that animal. Here, we demonstrate that Mason-Pfizer monkey virus (MPMV) is resistant to inhibition by the APOBEC3G protein expressed in its normal host, the rhesus macaque, but highly susceptible to inhibition by murine APOBEC3 (mA3). MPMV virion particles fail to package rhesus APOBEC3G (rA3G), and MPMV Gag binds rA3G poorly in coexpressing cells. In contrast, MPMV virions package mA3 efficiently and MPMV Gag-mA3 complexes are readily detected. Moreover, mA3, but not rA3G, partially colocalizes with MPMV Gag in the cytoplasm of coexpressing cells. Previously, we have demonstrated that murine leukemia virus also escapes inhibition by APOBEC3 proteins by avoiding virion incorporation of its cognate APOBEC3 protein, mA3, yet is inhibited by primate APOBEC3G proteins, which it packages effectively (B. P. Doehle, A. Schäfer, H. L. Wiegand, H. P. Bogerd, and B. R. Cullen, J. Virol. 79:8201-8207, 2005). The finding that two essentially unrelated beta- and gammaretroviruses use similar mechanisms to escape inhibition by the APOBEC3 proteins found in their normal host species suggests that the selective exclusion of APOBEC3 proteins from virion particles may be a general mechanism used by simple mammalian retroviruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.