ArticleJournal of virology2007
NKG2C+ NK cells are enriched in AIDS patients with advanced-stage Kaposi's sarcoma.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- IL-12-producing monocytes and HLA-E control HCMV-driven NKG2C+ NK cell expansion.The Journal of clinical investigation · 2014Trial
- Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications.Archivum immunologiae et therapiae experimentalis · 2023Review
- CXCR6Frontiers in immunology · 2022Article
- Prospects for NK Cell Therapy of Sarcoma.Cancers · 2020Review
- Tonsillar CD56brightNKG2A+ NK cells restrict primary Epstein-Barr virus infection in B cells via IFN-γ.Oncotarget · 2017Article
- High-resolution phenotyping identifies NK cell subsets that distinguish healthy children from adults.PloS one · 2017Article
- Hepatitis C Virus and Human Cytomegalovirus-Natural Killer Cell Subsets in Persistent Viral Infections.Frontiers in immunology · 2017Review
- Genetic Causes of Human NK Cell Deficiency and Their Effect on NK Cell Subsets.Frontiers in immunology · 2016Review
- NK Cell Influence on the Outcome of Primary Epstein-Barr Virus Infection.Frontiers in immunology · 2016Review
- The natural killer cell interferon-gamma response to bacteria is diminished in untreated HIV-1 infection and defects persist despite viral suppression.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry.Science translational medicine · 2013Article
- Killing of Kaposi's sarcoma-associated herpesvirus-infected fibroblasts during latent infection by activated natural killer cells.European journal of immunology · 2011Article
- Conserved T cell and natural killer cell function in treatment-experienced adults receiving tenofovir plus didanosine as nucleoside reverse transcription inhibitor backbone.Clinical and experimental immunology · 2009Article
- Role of natural killer cells in HIV pathogenesis.Current HIV/AIDS reports · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kaposi's sarcoma (KS) is an AIDS-defining condition in individuals with human immunodeficiency virus type 1 infection. We investigated the phenotype and function of the NKG2C+ NK cell population in individuals with AIDS and Kaposi's sarcoma. The staging of AIDS KS patients according to the AIDS Clinical Trial Group criteria revealed that patients with the S1 disease stage have a significantly higher proportion of NKG2C+ cells than those with the S0 disease stage. NKG2C+ cells from S1-stage patients are highly enriched for the expression of KIR3DL1, are depleted of NKp46, and respond poorly to major histocompatibility complex class I-positive target cells. These data demonstrate a link between NK cell phenotype and function and disease prognosis in AIDS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.