ArticleThe British journal of ophthalmology2007
Photoreceptor mitochondrial oxidative stress in early experimental autoimmune uveoretinitis.
Article in The British journal of ophthalmology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
- Oxidative Stress and Uveitis: Molecular Mechanisms and Pathogenetic Role.Current issues in molecular biology · 2026Review
- Prevalence and Clinical Characteristics of Dark Without Pressure Retinal Changes in a Chinese Hospital-Based Population.Ophthalmology and therapy · 2025Article
- Fundus autofluorescence in uveitis: from pathogenesis to imaging interpretation.International ophthalmology · 2023Review
- Local Myeloid-Derived Suppressor Cells Impair Progression of Experimental Autoimmune Uveitis by Alleviating Oxidative Stress and Inflammation.Investigative ophthalmology & visual science · 2023Article
- Immunological consequences of compromised ocular immune privilege accelerate retinal degeneration in retinitis pigmentosa.Orphanet journal of rare diseases · 2022Article
- Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets.Anatomy & cell biology · 2022Review
- Attenuation of Experimental Autoimmune Uveitis in Lewis Rats by Betaine.Experimental neurobiology · 2021Article
- Photoreceptor cells and RPE contribute to the development of diabetic retinopathy.Progress in retinal and eye research · 2021Review
- The Efficacy of Adalimumab as an Initial Treatment in Patients with Behçet's Retinal Vasculitis.Frontiers in pharmacology · 2021Article
- Suppression of the Reactive Oxygen Response Alleviates Experimental Autoimmune Uveitis in Mice.International journal of molecular sciences · 2020Article
- Three-dimensional automated reporter quantification (3D-ARQ) technology enables quantitative screening in retinal organoids.Development (Cambridge, England) · 2017Article
- Imaging in tuberculosis-associated uveitis.Indian journal of ophthalmology · 2017Review
- Photoreceptor Cells Produce Inflammatory Mediators That Contribute to Endothelial Cell Death in Diabetes.Investigative ophthalmology & visual science · 2016Article
- Expression Profile of Cationic Amino Acid Transporters in Rats with Endotoxin-Induced Uveitis.Mediators of inflammation · 2016Article
- Correlation between Fluorescein Angiographic Findings and Visual Acuity in Behçet Retinal Vasculitis.Yonsei medical journal · 2015Article
- Spontaneous remission of acute zonal occult outer retinopathy: follow-up using adaptive optics scanning laser ophthalmoscopy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2015Article
- Macrophages and Uveitis in Experimental Animal Models.Mediators of inflammation · 2015Review
- Role of autofluorescence in inflammatory/infective diseases of the retina and choroid.Journal of ophthalmology · 2014Review
- Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Sympathetic ophthalmia: to the twenty-first century and beyond.Journal of ophthalmic inflammation and infection · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
aimsIn early S-antigen induced experimental uveitis (EAU), photoreceptor mitochondrial proteins are nitrated prior to macrophage infiltration of the retina, suggesting that oxidative stress is an initial event in the development of EAU. We attempted to detect the oxidative stress and localise it in the EAU retina.
methodsLewis rats were immunised with S-antigen in complete Freund's adjuvant (CFA). Animals were injected with CFA alone and non-immunised animals served as controls. Immunised and non-immunised animals were killed on day 5 and subsequent days. Isolated retinas were processed for inducible nitric oxide synthase (iNOS), tumour necrosis factor (TNF)alpha, interferon (IFN)gamma, interleukin (IL)Ialpha and CD28 expression by real time polymerase chain reaction. In addition, iNOS was colocalised with cytochrome c oxidase on day 5 of EAU. Oxidative stress was detected by 2', 7'-dichlorodihydrofluorescein diacetate and localised by a mitochondrial specific marker. Leucocyte and T cell infiltration in the retina/choroid was evaluated by immunohistochemistry.
resultsThe iNOS, TNFalpha, IFNgamma, IL1alpha and CD28 transcripts were significantly upregulated on day 5 in EAU, and iNOS was colocalised with cytochrome c oxidase in the photoreceptor mitochondria. Oxidative stress was seen primarily in the photoreceptor mitochondria. Occasional T cells were present in the retina at this stage.
conclusionsDuring early EAU, mitochondrial oxidative stress is selectively noted in the photoreceptor inner segments. The oxidative stress appears to result from iNOS upregulation in the photoreceptor mitochondria and cytokine generation in the retina by a few antigen specific infiltrating T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.