ArticleThe British journal of ophthalmology2007
Clinical characteristics of Mooren's ulcer in South India.
Article in The British journal of ophthalmology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 63 citations in OpenAlex.
- Mooren's ulcer: a multifactorial autoimmune peripheral ulcerative keratitis and current treatment protocols.Frontiers in medicine · 2025Review
- High-altitude effect on corneal endothelial cells and prognosis in patients with cataract surgeries: a propensity score matched analysis.International journal of ophthalmology · 2025Article
- Surgical Management of Peripheral Ulcerative Keratitis: Update on Surgical Techniques and Their Outcome.Clinical ophthalmology (Auckland, N.Z.) · 2022Review
- Treatment of Mooren's ulcer coexisting with a pterygium using an intrastromal lenticule obtained from small-incision lenticule extraction: case report and literature review.The Journal of international medical research · 2021Review
- Peripheral ulcerative keratitis with corneal melt as the primary presentation in a case of human immunodeficiency virus.BMJ case reports · 2019Review
- Case report: bilateral Mooren ulcer in association with hepatitis C.BMC ophthalmology · 2017Article
- Rapid deterioration of Mooren's ulcers after conjunctival flap: a review of 2 cases.BMC ophthalmology · 2017Review
- Clinical Characteristics and Risk Factors of Recurrent Mooren's Ulcer.Journal of ophthalmology · 2017Article
- Partial lamellar keratoplasty for peripheral corneal disease using a graft from the glycerin-preserved corneoscleral rim.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2014Article
- Age distribution of various corneal diseases in China by histopathological examination of 3112 surgical specimens.Investigative ophthalmology & visual science · 2014Article
- Bilateral Mooren's ulcer in a child secondary to helminthic infestation of the gastrointestinal tract.International ophthalmology · 2012Article
- Update on peripheral ulcerative keratitis.Clinical ophthalmology (Auckland, N.Z.) · 2012Article
- Emerging role of antioxidants in the protection of uveitis complications.Current medicinal chemistry · 2011Review
- Etiology, clinical profile, and treatment outcome of peripheral ulcerative keratitis.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
- Peripheral Ulcerative Keratitis: A Review.Journal of ophthalmic & vision researchReview
- Mooren'S ulcer in ibadan, southwest Nigeria.Journal of the West African College of SurgeonsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo describe the clinical characteristics at presentation of a large cohort of patients with Mooren's ulcer in South India.
methodsThe medical records of patients with Mooren's ulcer examined in the cornea clinic at Aravind Eye Hospital Madurai, Tamil Nadu, India, over a 10-year period were reviewed in this retrospective observational case series.
resultsThe cohort contained 242 eyes of 166 patients. All patients were from South India, and men outnumbered women by a ratio of 4.7:1. The median and mean ages at presentation were 65 and 61 years, respectively, with a range of 13-95 years. One eye was affected in 90 of 166 (54%) patients. Visual acuity in the affected eye at presentation ranged from 6/6 to light perception, and was 6/12 or better in 34 of 242 (14%) eyes, between 6/12 and 3/60 in 168 (69%) eyes, and worse than 3/60 in 40 (17%) eyes. Partial peripheral corneal ulceration was observed in 222 (92%) eyes, complete peripheral corneal ulceration was observed in 15 (6%) eyes and total corneal ulceration was observed in 5 (2%) eyes. For those 222 eyes with partial peripheral ulceration, 152 (68%) showed temporal involvement, 129 (58%) showed nasal involvement, 116 (52%) showed inferior involvement and 30 (14%) showed superior involvement. Perforation was observed in 26 (11%) eyes, and was more common in eyes with peripheral as compared with total ulceration (p<0.001). Identified risk factors in the cohort included evidence of prior corneal surgery (22%), corneal trauma (17%) and corneal infection (2%).
conclusionsMooren's ulcer is a rare and potentially blinding eye condition observed not infrequently in the cornea clinic at Aravind Eye Hospital. Men are affected more often than women and may present with either unilateral or bilateral disease. Perforation is observed in approximately 1 in 10 affected eyes at presentation and occurs most often in the setting of peripheral ulceration. The occurrence of prior corneal surgery, trauma or infection in nearly one third of patients supports theories of exposure to corneal antigen in the pathogenesis of this disorder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.