ArticleBiochemical and biophysical research communications2006
Oxidative stress-induced intestinal epithelial cell apoptosis is mediated by p38 MAPK.
Article in Biochemical and biophysical research communications, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 60 citations in OpenAlex.
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- Naringenin Inhibits EnterotoxigenicAntioxidants (Basel, Switzerland) · 2025Article
- Impact of Diquat on the Intestinal Health and the Composition and Function of the Gut Microbiome.Antioxidants (Basel, Switzerland) · 2025Review
- CD38 Inhibition Protects Fructose-Induced Toxicity in Primary Hepatocytes.Molecules and cells · 2023Article
- New insights into intestinal macrophages in necrotizing enterocolitis: the multi-functional role and promising therapeutic application.Frontiers in immunology · 2023Review
- Lidocaine Ameliorates Diabetic Peripheral Neuropathy in Streptozotocin-Induced Diabetic Rats through Modulating the c-Jun Signaling Pathway.Contrast media & molecular imaging · 2022Article
- Diosmin Alleviates Doxorubicin-Induced Liver Injury via Modulation of Oxidative Stress-Mediated Hepatic Inflammation and Apoptosis via NfkB and MAPK Pathway: A Preclinical Study.Antioxidants (Basel, Switzerland) · 2021Article
- Comparative study on the antituberculous effect and mechanism of the traditional Chinese medicines NiuBeiXiaoHe extract and JieHeWan.Military Medical Research · 2021Article
- The effects of myeloablative or non-myeloablative total body irradiations on intestinal tract in mice.Bioscience reports · 2021Article
- Taurine Alleviates Intestinal Injury by Mediating Tight Junction Barriers in Diquat-Challenged Piglet Models.Frontiers in physiology · 2020Article
- Activation of the NF-Oxidative medicine and cellular longevity · 2020Article
- Characterization of Apoptosis, Autophagy and Oxidative Stress in Pancreatic Islets Cells and Intestinal Epithelial Cells Isolated from Equine Metabolic Syndrome (EMS) Horses.International journal of molecular sciences · 2018Article
- Data MiningInternational journal of genomics · 2018Article
- Intestinal injury following liver transplantation was mediated by TLR4/NF-κB activation-induced cell apoptosis.Molecular medicine reports · 2016Article
- Immunologic and Hematological Abnormalities in Necrotizing Enterocolitis.Clinics in perinatology · 2015Review
- Inflammatory signaling in NEC: Role of NF-κB, cytokines and other inflammatory mediators.Pathophysiology : the official journal of the International Society for Pathophysiology · 2014Article
- Inflammatory signaling in necrotizing enterocolitis.Clinics in perinatology · 2013Review
- Modulation of endoplasmic reticulum stress and cardiomyocyte apoptosis by mulberry leaf diet in experimental autoimmune myocarditis rats.Journal of clinical biochemistry and nutrition · 2012Article
- Inhibition of p38 mitogen-activated protein kinase phosphorylation decrease tert-butyl hydroperoxide-induced apoptosis in human trabecular meshwork cells.Molecular vision · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Free oxygen radicals are involved in the pathogenesis of necrotizing enterocolitis (NEC) in premature infants. The stress-activated p38 mitogen-activated protein kinase (MAPK) has been implicated in gut injury. Here, we found that phosphorylated p38 was detected primarily in the villus tips of normal intestine, whereas it was expressed in the entire mucosa in NEC. H(2)O(2) treatment resulted in a rapid phosphorylation of p38 MAPK and subsequent apoptosis of rat intestinal epithelial (RIE)-1 cells; this induction was attenuated by treatment with SB203580, a selective p38 MAPK inhibitor, or transfection with p38alpha siRNA. Moreover, SB203580 also blocked H(2)O(2)-induced PKC activation. In contrast, the PKC inhibitor (GF109203x) did not affect p38 activation, indicating that p38 MAPK activation occurs upstream of PKC activation in H(2)O(2)-induced apoptosis. H(2)O(2) treatment also decreased mitochondrial membrane potential; pretreatment with SB203580 attenuated this response. Our study demonstrates that the p38 MAPK/PKC pathway plays an important role as a pro-apoptotic cellular signaling during oxidative stress-induced intestinal epithelial cell injury.
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