ArticleRetrovirology2006
5' long terminal repeat (LTR)-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signals.
Article in Retrovirology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
62 citing papers in PubMed, 81 citations in OpenAlex.
- Breaking into HIV-1's Epigenetic Vault: Cure Strategies to Eliminate the Viral Reservoir.Viruses · 2026Review
- Epigenetic regulation of HIV-1 transcription: insights into latency mechanisms and therapeutic strategies.Frontiers in cellular and infection microbiology · 2026Review
- Human chromatin remodelers regulating HIV-1 transcription: a target for small molecule inhibitors.Epigenetics & chromatin · 2025Review
- Enhancer of zeste homolog 1/2 dual inhibitor valemetostat outperforms enhancer of zeste homolog 2-selective inhibitors in reactivating latent HIV-1 reservoirsFrontiers in microbiology · 2025Article
- Article
- Epigenetic Mechanisms of HIV-1 Persistence.Vaccines · 2021Review
- Human retroviral antisense mRNAs are retained in the nuclei of infected cells for viral persistence.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Deciphering DNA Methylation in HIV Infection.Frontiers in immunology · 2021Review
- Effect ofFrontiers in pharmacology · 2021Article
- ZBTB gene expression in HIV patients: a possible new molecular mechanism of viral control.Archives of virology · 2021Article
- Balance between Retroviral Latency and Transcription: Based on HIV Model.Pathogens (Basel, Switzerland) · 2020Review
- Review
- Regulation of Expression and Latency in BLV and HTLV.Viruses · 2020Review
- Review
- Epigenetic crosstalk in chronic infection with HIV-1.Seminars in immunopathology · 2020Review
- Molecular biology of human T cell leukemia virus.Seminars in diagnostic pathology · 2020Review
- Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals.Clinical epigenetics · 2020Article
- HIV-1 DNA-capture-seq is a useful tool for the comprehensive characterization of HIV-1 provirus.Scientific reports · 2019Article
- Variable BaselineFrontiers in immunology · 2019Article
- Barriers for HIV Cure: The Latent Reservoir.AIDS research and human retroviruses · 2018Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously described selective hypermethylation of the 5'-long terminal repeat (LTR) of HTLV-1 provirus in vivo and in vitro. This prompted us to analyze CpG methylation of the two LTRs of the HIV provirus in chronically infected cell lines. The results demonstrate selective hypermethylation of the 5' LTR of the HIV provirus in ACH-2 cells. Moreover, induction of viral gene expression by TNF-alpha resulted in demethylation of the 5'-LTR. These results suggest that selective epigenetic modification of the 5'LTR of the HIV-1 provirus may be an important mechanism by which proviral activity is suppressed.
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Registered trials
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