ArticleClinical and experimental immunology2006
Innate immune peptide LL-37 displays distinct expression pattern from beta-defensins in inflamed gingival tissue.
Article in Clinical and experimental immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 115 citations in OpenAlex.
- Changes in salivary antimicrobial peptides, immunoglobulin A and cortisol after prolonged strenuous exercise.European journal of applied physiology · 2011Trial
- A Comparative Analysis of Cell Proliferation and Wound Closure in Cultured Gingival Epithelial Cells Using Plasma Rich in Growth Factors and Platelet-Rich Plasma Containing Leukocytes.European journal of dentistry · 2025Article
- A Simple Synthesis and Microstructure Analysis of Human Peptide LL-37@Gold Nanoparticles (Known as LL-37@AuNPs) Conjugates as Antimicrobials and Substances for Wound Healing.Materials (Basel, Switzerland) · 2023Article
- Antimicrobial Peptides and Interleukins in Cleft Soft Palate.Children (Basel, Switzerland) · 2023Article
- The Antimicrobial Peptide LL-37 as a Predictor Biomarker for Periodontitis with the Presence and Absence of Smoking: A Case-Control Study.BioMed research international · 2023Article
- Riemerella anatipestifer T9SS Effector SspA Functions in Bacterial Virulence and Defending Natural Host Immunity.Applied and environmental microbiology · 2022Article
- Gingival Transcriptome of Innate Antimicrobial Factors and the Oral Microbiome With Aging and Periodontitis.Frontiers in oral health · 2022Article
- Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?International journal of implant dentistry · 2020Article
- Article
- Significance of LL-37 on Immunomodulation and Disease Outcome.BioMed research international · 2020Review
- Transplantation of periodontal ligament cell sheets expressing human β‑defensin‑3 promotes anti‑inflammation in a canine model of periodontitis.Molecular medicine reports · 2017Article
- Expression and antimicrobial character of cells transfected with human β‑defensin‑3 against periodontitis‑associated microbiota in vitro.Molecular medicine reports · 2017Article
- Gingival crevicular fluid and serum hCAP18/LL-37 levels in generalized aggressive periodontitis.Clinical oral investigations · 2017Article
- Mirolysin, a LysargiNase from Tannerella forsythia, proteolytically inactivates the human cathelicidin, LL-37.Biological chemistry · 2017Article
- Levels of ll-37 antimicrobial peptide in the gingival crevicular fluid of young and middle-aged subjects with or without gingivitis.Journal of Istanbul University Faculty of Dentistry · 2017Article
- Hydrogen Sulfide, Oxidative Stress and Periodontal Diseases: A Concise Review.Antioxidants (Basel, Switzerland) · 2016Review
- Establishment of Epithelial Attachment on Titanium Surface Coated with Platelet Activating Peptide.PloS one · 2016Article
- Mirolase, a novel subtilisin-like serine protease from the periodontopathogen Tannerella forsythia.Biological chemistry · 2015Article
- Salivary Antimicrobial Peptides in Early Detection of Periodontitis.Frontiers in cellular and infection microbiology · 2015Review
- Roles of cathelicidins in inflammation and bone loss.Odontology · 2014Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Anti-microbial peptides produced from mucosal epithelium appear to play pivotal roles in the host innate immune defence system in the oral cavity. In particular, human beta-defensins (hBDs) and the cathelicidin-type anti-microbial peptide, LL-37, were reported to kill periodontal disease-associated bacteria. In contrast to well-studied hBDs, little is known about the expression profiles of LL-37 in gingival tissue. In this study, the anti-microbial peptides expressed in gingival tissue were analysed using immunohistochemistry and enxyme-linked immunosorbent assay (ELISA). Immunohistochemistry revealed that neutrophils expressed only LL-37, but not hBD-2 or hBD-3, and that such expression was prominent in the inflammatory lesions when compared to healthy gingivae which showed very few or no LL-37 expressing neutrophils. Gingival epithelial cells (GEC), however, expressed all three examined anti-microbial peptides, irrespective of the presence or absence of inflammation. Moreover, as determined by ELISA, the concentration of LL-37 in the gingival tissue homogenates determined was correlated positively with the depth of the gingival crevice. Stimulation with periodontal bacteria in vitro induced both hBD-2 and LL-37 expressions by GEC, whereas peripheral blood neutrophils produced only LL-37 production, but not hBD-2, in response to the bacterial stimulation. These findings suggest that LL-37 displays distinct expression patterns from those of hBDs in gingival tissue.
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