ArticleJournal of bioenergetics and biomembranes2006
PRUNE and NM23-M1 expression in embryonic and adult mouse brain.
Article in Journal of bioenergetics and biomembranes, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Architects of the Developing Brain: Cytoskeleton-Organizing Molecules in Neurodevelopmental Disorders.Cells · 2026Review
- Integrating brain proteomes and genetics to identify novel risk genes in chronic widespread musculoskeletal pain.Scientific reports · 2025Article
- PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases.Cancer metastasis reviews · 2024Review
- Article
- PRUNE1 c.933G>A synonymous variant induces exon 7 skipping, disrupts the DHHA2 domain, and leads to an atypical NMIHBA syndrome presentation: Case report and review of the literature.American journal of medical genetics. Part A · 2022Review
- NME1 Protects Against Neurotoxin-, α-Synuclein- and LRRK2-Induced Neurite Degeneration in Cell Models of Parkinson's Disease.Molecular neurobiology · 2022Article
- NMIHBA results from hypomorphic PRUNE1 variants that lack short-chain exopolyphosphatase activity.Human molecular genetics · 2021Article
- Functional Genomics of PRUNE1 in Neurodevelopmental Disorders (NDDs) Tied to Medulloblastoma (MB) and Other Tumors.Frontiers in oncology · 2021Review
- The Metastasis Suppressor Protein Nme1 Is a Concentration-Dependent Modulator of CaBiochemistry · 2019Article
- A competitive cell-permeable peptide impairs Nme-1 (NDPK-A) and Prune-1 interaction: therapeutic applications in cancer.Laboratory investigation; a journal of technical methods and pathology · 2018Review
- Extracellular NME proteins: a player or a bystander?Laboratory investigation; a journal of technical methods and pathology · 2018Review
- The phenotypic and molecular spectrum of PEHO syndrome and PEHO-like disorders.Brain : a journal of neurology · 2017Article
- PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment.Brain : a journal of neurology · 2017Article
- High inorganic triphosphatase activities in bacteria and mammalian cells: identification of the enzymes involved.PloS one · 2012Article
- The NME gene family in zebrafish oogenesis and early development.Naunyn-Schmiedeberg's archives of pharmacology · 2011Article
- The Nm23-H1-h-Prune complex in cellular physiology: a 'tip of the iceberg' protein network perspective.Molecular and cellular biochemistry · 2009Review
- Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1.Neural development · 2009Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A genetic interaction between PRUNE and NM23/NDPK has been postulated in Drosophila melanogaster. Many have focused on Drosophila for the genetic combination between PRUNE "knock down" and AWD/NM23 fly mutants bearing the P97S mutation (K-pn, Killer of PRUNE mutation). We postulated a role for PRUNE-NM23 interactions in vertebrate development, demonstrating a physical interaction between the human PRUNE and NM23-H1 proteins, and partially characterizing their functional significance in cancer progression. Here, we present an initial analysis towards the functional characterization of the PRUNE-NM23 interaction during mammalian embryogenesis. Our working hypothesis is that PRUNE, NM23-H1 and their protein-protein interaction partners have important roles in mammalian brain development and adult brain function. Detailed expression analyses from early mouse brain development to adulthood show significant co-expression of these two genes during embryonic stages of brain development, especially focusing on the cortex, hippocampus, midbrain and cerebellum. We hypothesize that their abnormal expression results in an altered pathway of activation, influencing protein complex formation and its protein partner interactions in early embryogenesis. In the adult brain, their function appears concentrated towards their enzyme activities, wherein biochemical variations can result in brain dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.