ArticleActa neuropathologica1990
Clinicopathologic correlations in epithelial choroid plexus neoplasms: a study of 52 cases.
Article in Acta neuropathologica, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Choroid plexus tumours.British journal of cancer · 2002Pooled it
- The composition of choroid plexus tumor research: a bibliometric analysis of the 100 most impactful studies to date.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Primary papillary epithelial tumor of the sella and posterior pituitary tumor show similar (epi)genetic features and constitute a single neuro-oncological entity.Neuro-oncology · 2023Article
- Article
- Choroid plexus and the blood-cerebrospinal fluid barrier in disease.Fluids and barriers of the CNS · 2020Review
- Neuropathology as a Life-Task.Free neuropathology · 2020Article
- Effects of adjuvant chemotherapy and radiation on overall survival in children with choroid plexus carcinoma.Journal of neuro-oncology · 2014Article
- Gross total resection improves overall survival in children with choroid plexus carcinoma.Journal of neuro-oncology · 2014Article
- Choroid plexus papillomas: advances in molecular biology and understanding of tumorigenesis.Neuro-oncology · 2013Review
- Choroid plexus tumors: A clinico-pathological and neuro-radiological study of 23 cases.Asian journal of neurosurgery · 2013Article
- Unusual radiologic findings and pathologic growth patterns on choroid plexus papillomas.Journal of Korean Neurosurgical Society · 2012Article
- A novel TP53 somatic mutation involved in the pathogenesis of pediatric choroid plexus carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Which therapy works better in choroid plexus carcinomas?Journal of neuro-oncology · 2011Article
- Clinicopathologic and immunohistochemical study of choroid plexus tumors: single-institution experience in Mexican population.Journal of neuro-oncology · 2010Article
- Atypical choroid plexus papilloma in an adult.Journal of Korean Neurosurgical Society · 2009Article
- Spinal drop metastasis from a posterior fossa choroid plexus papilloma.Journal of Korean Neurosurgical Society · 2007Article
- Choroid plexus carcinomas in children: MRI features and patient outcomes.Neuroradiology · 2004Article
- Chromosomal imbalances in choroid plexus tumors.The American journal of pathology · 2002Article
- Differential expression of cell adhesion molecules (CAM), neural CAM and epithelial cadherin in ependymomas and choroid plexus tumors.Acta neuropathologica · 1995Article
- Choroid plexus tumors in childhood. Histopathologic study and clinico-pathological correlation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 1991Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sixty-seven tumor specimens of epithelial choroid plexus neoplasms obtained by 60 biopsies and 7 autopsies from 52 patients were investigated. Diagnoses of the first operations were choroid plexus papilloma (PP; 32 cases), choroid plexus papilloma with histological atypies (atypical PP; 6 cases), and choroid plexus carcinoma (PC; 14 cases). Carcinoembryonic antigen was expressed by 2 of the 3 biopsies autoptically recognized as metastatic carcinomas and by 2 autopsy cases of PC, while it was absent in all biopsies of true choroid plexus tumors. Tumor cells positive for transthyretin (TTR, prealbumin), S-100 protein (S100), and glial fibrillary acidic protein (GFAP) were detected in 39, 46 and 13, respectively, of the 49 cases of true choroid plexus tumors. Fourth ventricle tumors expressed more S100 (number of positive tumor cells) than lateral ventricle tumors, PP more S100 and TTR than atypical PP/PC. Tumors from patients 20 years of age and older expressed more GFAP and TTR than tumors from younger patients. Of the 30 patients with complete follow-up 19 were alive 2 to 11 years after surgery, including 7 recurrencies. Eleven died from the tumor 4 months to 7 years after surgery. The following histopathologic features (in order of decreasing significance) were correlated with poor prognosis (recurrency or fatal outcome): less than 50% of the tumor cells heavily positive for S100, presence of mitoses, absence of TTR-positive cells, brain invasion by cell nests, absence of marked stromal edema, and presence of necrotic areas. Our results indicate that some histologic features correlate significantly with poor prognosis and that immunohistochemical results correlate with tumor localization, age, and malignancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.