ArticleBiological procedures online2006
Chromatin immunoprecipitation assay detects ERalpha recruitment to gene specific promoters in uterus.
Article in Biological procedures online, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Nucleolar Sik-similar protein (Sik-SP) is required for the maintenance of uterine estrogen signaling mechanism via ERα.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity.Developmental cell · 2011Article
- Suppression of ERalpha activity by COUP-TFII is essential for successful implantation and decidualization.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Selective disruption of ER{alpha} DNA-binding activity alters uterine responsiveness to estradiol.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen.Molecular endocrinology (Baltimore, Md.) · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Chromatin immunoprecipitation (ChIP) technique allows detection of proteins that bind to chromatin. While this technique has been applied extensively in cell-based studies, its tissue-based application remains poorly explored. We are specifically interested in examining estrogen-dependent transcriptional mechanism in respect of recruitment of estrogen receptor-alpha (ERalpha), a ligand-activated transcription factor, to uterine gene promoters in mice. Recent gene-array studies, utilizing ERalpha knock-out vs. wild-type mice, have revealed that estrogen regulates numerous uterine genes temporally and most importantly via ERalpha during the phase-II response, including three well characterized genes viz., lactoferrin (Ltf), progesterone receptor (Pgr) and cyclinD1 (Ccnd1). Here, utilizing systematic ChIP studies, we demonstrate endogenous recruitment of ERalpha to above uterine gene promoters following estradiol-17beta (E(2)) injection in mice.
Identifiers
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Registered trials
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