ArticleBMC genomics2006
Analysis of the dermatophyte Trichophyton rubrum expressed sequence tags.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Host-Pathogen Interaction and Resistance Mechanisms in Dermatophytes.Pathogens (Basel, Switzerland) · 2024Review
- Founder Effects Contribute to the Population Genetic Structure of the Major Dermatophytosis PathogenClinical, cosmetic and investigational dermatology · 2021Article
- Genes Encoding Proteolytic Enzymes Fungalysin and Subtilisin in Dermatophytes of Human and Animal Origin: A Comparative Study.Mycopathologia · 2020Article
- Integrated microRNA and mRNA analysis in the pathogenic filamentous fungus Trichophyton rubrum.BMC genomics · 2018Article
- The first succinylome profile of Trichophyton rubrum reveals lysine succinylation on proteins involved in various key cellular processes.BMC genomics · 2017Article
- Genetic Manipulations in Dermatophytes.Mycopathologia · 2017Review
- Identification and characterisation of non-coding small RNAs in the pathogenic filamentous fungus Trichophyton rubrum.BMC genomics · 2013Article
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- Transcriptional profiling reveals the expression of novel genes in response to various stimuli in the human dermatophyte Trichophyton rubrum.BMC microbiology · 2010Article
- Development of transformation system for Trichophyton rubrum by electroporation of germinated conidia.Current genetics · 2009Article
- Recent dermatophyte divergence revealed by comparative and phylogenetic analysis of mitochondrial genomes.BMC genomics · 2009Article
- Gene expression profiling in the human pathogenic dermatophyte Trichophyton rubrum during growth on proteins.Eukaryotic cell · 2009Article
- Proteomic profile of dormant Trichophyton rubrum conidia.BMC genomics · 2008Article
- TrED: the Trichophyton rubrum Expression Database.BMC genomics · 2007Article
- Article
- Pathogenesis of dermatophytosis.MycopathologiaReview
Corrections and comments
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDermatophytes are the primary causative agent of dermatophytoses, a disease that affects billions of individuals worldwide. Trichophyton rubrum is the most common of the superficial fungi. Although T. rubrum is a recognized pathogen for humans, little is known about how its transcriptional pattern is related to development of the fungus and establishment of disease. It is therefore necessary to identify genes whose expression is relevant to growth, metabolism and virulence of T. rubrum.
resultsWe generated 10 cDNA libraries covering nearly the entire growth phase and used them to isolate 11,085 unique expressed sequence tags (ESTs), including 3,816 contigs and 7,269 singletons. Comparisons with the GenBank non-redundant (NR) protein database revealed putative functions or matched homologs from other organisms for 7,764 (70%) of the ESTs. The remaining 3,321 (30%) of ESTs were only weakly similar or not similar to known sequences, suggesting that these ESTs represent novel genes.
conclusionThe present data provide a comprehensive view of fungal physiological processes including metabolism, sexual and asexual growth cycles, signal transduction and pathogenic mechanisms.
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