ArticleAnnals of biomedical engineering2006
Three-dimensional numerical modeling and computational fluid dynamics simulations to analyze and improve oxygen availability in the AMC bioartificial liver.
Article in Annals of biomedical engineering, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 44 citations in OpenAlex.
- Generation and evaluation of input values for computational analysis of transport processes within tissue cultures.Engineering in life sciences · 2022Review
- Design and Fabrication of a Liver-on-a-chip Reconstructing Tissue-tissue Interfaces.Frontiers in oncology · 2022Article
- The liver, a functionalized vascular structure.Scientific reports · 2020Article
- Next-generation polymerized human hemoglobins in hepatic bioreactor simulations.Biotechnology progress · 2020Article
- Liver Bioreactor Design Issues of Fluid Flow and Zonation, Fibrosis, and Mechanics: A Computational Perspective.Journal of functional biomaterials · 2020Review
- Three-dimensional culture in a microgravity bioreactor improves the engraftment efficiency of hepatic tissue constructs in mice.Journal of materials science. Materials in medicine · 2014Article
- Bioreactor technologies to support liver function in vitro.Advanced drug delivery reviews · 2014Review
- Hemoglobin regulates the metabolic, synthetic, detoxification, and biotransformation functions of hepatoma cells cultured in a hollow fiber bioreactor.Tissue engineering. Part A · 2010Article
- Imaging glucose metabolism in perfluorocarbon-perfused hepatocyte bioreactors using positron emission tomography.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2009Article
- Review
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A numerical model to investigate fluid flow and oxygen (O(2)) transport and consumption in the AMC-Bioartificial Liver (AMC-BAL) was developed and applied to two representative micro models of the AMC-BAL with two different gas capillary patterns, each combined with two proposed hepatocyte distributions. Parameter studies were performed on each configuration to gain insight in fluid flow, shear stress distribution and oxygen availability in the AMC-BAL. We assessed the function of the internal oxygenator, the effect of changes in hepatocyte oxygen consumption parameters in time and the effect of the change from an experimental to a clinical setting. In addition, different methodologies were studied to improve cellular oxygen availability, i.e. external oxygenation of culture medium, culture medium flow rate, culture gas oxygen content (pO(2)) and the number of oxygenation capillaries. Standard operating conditions did not adequately provide all hepatocytes in the AMC-BAL with sufficient oxygen to maintain O(2) consumption at minimally 90% of maximal uptake rate. Cellular oxygen availability was optimized by increasing the number of gas capillaries and pO(2) of the oxygenation gas by a factor two. Pressure drop over the AMC-BAL and maximal shear stresses were low and not considered to be harmful. This information can be used to increase cellular efficiency and may ultimately lead to a more productive AMC-BAL.
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Registered trials
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