ArticleThe Journal of cell biology2006
Dynamic microtubules are essential for efficient chromosome capture and biorientation in S. cerevisiae.
Article in The Journal of cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Telomeres in mitosis: organization and dynamics.Nucleus (Austin, Tex.) · 2026Review
- Article
- The EB1-Kinesin-14 complex is required for efficient metaphase spindle assembly and kinetochore bi-orientation.The Journal of cell biology · 2020Article
- Microtubule dynamics regulation reconstituted in budding yeast lysates.Journal of cell science · 2018Article
- Mechanism of nuclear movements in a multinucleated cell.Molecular biology of the cell · 2017Article
- Article
- Structure-function analysis of yeast tubulin.Methods in cell biology · 2013Article
- Constitutive dynein activity in She1 mutants reveals differences in microtubule attachment at the yeast spindle pole body.Molecular biology of the cell · 2012Article
- Involvement of PKCζ and GSK3β in the stability of the metaphase spindle.In vitro cellular & developmental biology. Animal · 2012Article
- Ipl1/Aurora-dependent phosphorylation of Sli15/INCENP regulates CPC-spindle interaction to ensure proper microtubule dynamics.The Journal of cell biology · 2011Article
- Mutation of Ser172 in yeast β tubulin induces defects in microtubule dynamics and cell division.PloS one · 2010Article
- Irc15 Is a microtubule-associated protein that regulates microtubule dynamics in Saccharomyces cerevisiae.Current biology : CB · 2009Article
- Chromosome congression by Kinesin-5 motor-mediated disassembly of longer kinetochore microtubules.Cell · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Attachment of chromosomes to the mitotic spindle has been proposed to require dynamic microtubules that randomly search three-dimensional space and become stabilized upon capture by kinetochores. In this study, we test this model by examining chromosome capture in Saccharomyces cerevisiae mutants with attenuated microtubule dynamics. Although viable, these cells are slow to progress through mitosis. Preanaphase cells contain a high proportion of chromosomes that are attached to only one spindle pole and missegregate in the absence of the spindle assembly checkpoint. Measurement of the rates of chromosome capture and biorientation demonstrate that both are severely decreased in the mutants. These results provide direct evidence that dynamic microtubules are critical for efficient chromosome capture and biorientation and support the hypothesis that microtubule search and capture plays a central role in assembly of the mitotic spindle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.