ArticleProceedings of the National Academy of Sciences of the United States of America2006
Eph tyrosine kinase receptor EphA4 is required for the topographic mapping of the corticospinal tract.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 29 citations in OpenAlex.
- Incorporating Combinatorial Approaches to Encourage Targeted Neural Stem/Progenitor Cell Integration Following Transplantation in Spinal Cord Injury.Stem cells translational medicine · 2023Review
- Inter-Regional Proteomic Profiling of the Human Brain Using an Optimized Protein Extraction Method from Formalin-Fixed Tissue to Identify Signaling Pathways.International journal of molecular sciences · 2023Article
- Human urine-derived stem cell-derived exosomal miR-21-5p promotes neurogenesis to attenuate Rett syndrome via the EPha4/TEK axis.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- EphA4 Is Required for Neural Circuits Controlling Skilled Reaching.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Focal Stroke in the Developing Rat Motor Cortex Induces Age- and Experience-Dependent Maladaptive Plasticity of Corticospinal System.Frontiers in neural circuits · 2017Article
- EphA4 protein promotes invasion in clear cell renal cell carcinomas.International journal of clinical and experimental pathology · 2017Article
- Endothelial-Specific EphA4 Negatively Regulates Native Pial Collateral Formation and Re-Perfusion following Hindlimb Ischemia.PloS one · 2016Article
- Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord.Neural regeneration research · 2013Article
- High-content analysis of proapoptotic EphA4 dependence receptor functions using small-molecule libraries.Journal of biomolecular screening · 2012Article
- Differential gene expression in the EphA4 knockout spinal cord and analysis of the inflammatory response following spinal cord injury.PloS one · 2012Article
- Expression profile and role of EphrinA1 ligand after spinal cord injury.Cellular and molecular neurobiology · 2011Article
- EphA4 is necessary for spatially selective peripheral somatosensory topography.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling.Structure (London, England : 1993) · 2009Article
- Activity- and use-dependent plasticity of the developing corticospinal system.Neuroscience and biobehavioral reviews · 2007Review
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Fine movement in the body is controlled by the motor cortex, which signals in a topographically specific manner to neurons in the spinal cord by means of the corticospinal tract (CST). How the correct topography of the CST is established is unknown. To investigate the possibility that the Eph tyrosine kinase receptor EphA4 is involved in this process, we have traced CST axons in mice in which the EphA4 gene has been deleted. The forelimb subpopulation of CST axons is unaffected in the EphA4-/- mice, but the hindlimb subpopulation branches too early within the cord, both temporally and spatially. EphA4 shows a dynamic expression pattern in the environment of the developing CST in the spinal cord: high at the time of forelimb branching and down-regulated before hindlimb branching. To examine whether the fore- and hindlimb subpopulations of CST axons respond differently to EphA4 in their environment, neurons from fore- and hindlimb motor cortex were cultured on a substrate containing EphA4. Neurons from the hindlimb cortex showed reduced branching on the EphA4 substrate compared with their forelimb counterparts. Neurons from the hindlimb cortex express ephrinA5, a high-affinity ligand for EphA4, at higher levels compared with forelimb cortex neurons, and this expression is down-regulated before hindlimb branching. Together, these findings suggest that EphA4 regulates topographic mapping of the CST by controlling the branching of CST axons in the spinal cord.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.