ArticleMolecular and cellular biology2007
AUF1 cell cycle variations define genomic DNA methylation by regulation of DNMT1 mRNA stability.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
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- Sodium salicylate reduced mRNA abundance of hypoxia-associated genes in MAC-T cells.JDS communications · 2021Article
- Methotrexate impaired in-vivo matured mouse oocyte quality and the possible mechanisms.BMC molecular and cell biology · 2020Article
- Epigenetics and cell cycle regulation in cystogenesis.Cellular signalling · 2020Review
- Guidance of circular RNAs to proteins' behavior as binding partners.Cellular and molecular life sciences : CMLS · 2019Review
- A circular RNA circ-DNMT1 enhances breast cancer progression by activating autophagy.Oncogene · 2018Article
- Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each.PloS one · 2018Article
- Efficient translation of Dnmt1 requires cytoplasmic polyadenylation and Musashi binding elements.PloS one · 2014Article
- An insight into the various regulatory mechanisms modulating human DNA methyltransferase 1 stability and function.Epigenetics · 2012Review
- Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP.Nucleic acids research · 2012Article
- Review
- hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing.The Journal of clinical investigation · 2010Article
- Circadian amplitude of cryptochrome 1 is modulated by mRNA stability regulation via cytoplasmic hnRNP D oscillation.Molecular and cellular biology · 2010Article
- Members of the NuRD chromatin remodeling complex interact with AUF1 in developing cortical neurons.Cerebral cortex (New York, N.Y. : 1991) · 2008Article
- The role of DNA hypermethylation and demethylation in cancer and cancer therapy.Current oncology (Toronto, Ont.) · 2008Article
- A method for purification, identification and validation of DNMT1 mRNA binding proteins.Biological procedures online · 2008Article
- The role of AUF1 in regulated mRNA decay.Wiley interdisciplinary reviews. RNAReview
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
DNA methylation is a major determinant of epigenetic inheritance. DNA methyltransferase 1 (DNMT1) is the enzyme responsible for the maintenance of DNA methylation patterns during cell division, and deregulated expression of DNMT1 leads to cellular transformation. We show herein that AU-rich element/poly(U)-binding/degradation factor 1 (AUF1)/heterogeneous nuclear ribonucleoprotein D interacts with an AU-rich conserved element in the 3' untranslated region of the DNMT1 mRNA and targets it for destabilization by the exosome. AUF1 protein levels are regulated by the cell cycle by the proteasome, resulting in cell cycle-specific destabilization of DNMT1 mRNA. AUF1 knock down leads to increased DNMT1 expression and modifications of cell cycle kinetics, increased DNA methyltransferase activity, and genome hypermethylation. Concurrent AUF1 and DNMT1 knock down abolishes this effect, suggesting that the effects of AUF1 knock down on the cell cycle are mediated at least in part by DNMT1. In this study, we demonstrate a link between AUF1, the RNA degradation machinery, and maintenance of the epigenetic integrity of the cell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.