ArticleMolecular and cellular biology2006
Imp associates with squid and Hrp48 and contributes to localized expression of gurken in the oocyte.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Emerging Roles of RNA-Binding Proteins in Neurodevelopment.Journal of developmental biology · 2022Review
- Article
- Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation.PLoS genetics · 2020Article
- Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation.eLife · 2019Article
- Article
- IMP regulates Kuzbanian to control the timing of Notch signalling inDevelopment (Cambridge, England) · 2019Article
- Hrp48 and eIF3d contribute to msl-2 mRNA translational repression.Nucleic acids research · 2018Article
- Cellular diversity in theeLife · 2018Article
- The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells.eLife · 2018Article
- Review
- Imp and Syp RNA-binding proteins govern decommissioning ofDevelopment (Cambridge, England) · 2017Article
- Regulation of Notch Signaling by the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex inGenetics · 2017Article
- Community effects in regulation of translation.eLife · 2016Article
- A high-throughput pipeline for the production of synthetic antibodies for analysis of ribonucleoprotein complexes.RNA (New York, N.Y.) · 2016Article
- Drosophila Imp iCLIP identifies an RNA assemblage coordinating F-actin formation.Genome biology · 2015Article
- In the right place at the right time: visualizing and understanding mRNA localization.Nature reviews. Molecular cell biology · 2015Review
- Use of Drosophila as an evaluation method reveals imp as a candidate gene for type 2 diabetes in rat locus Niddm22.Journal of diabetes research · 2015Article
- Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?Cellular and molecular life sciences : CMLS · 2013Review
- Article
- The hnRNP A1 homolog Hrp36 is essential for normal development, female fecundity, omega speckle formation and stress tolerance in Drosophila melanogaster.Journal of biosciences · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Localization and translational control of Drosophila melanogaster gurken and oskar mRNAs rely on the hnRNP proteins Squid and Hrp48, which are complexed with one another in the ovary. Imp, the Drosophila homolog of proteins acting in localization of mRNAs in other species, is also associated with Squid and Hrp48. Notably, Imp is concentrated at sites of gurken and oskar mRNA localization in the oocyte, and alteration of gurken localization also alters Imp distribution. Imp binds gurken mRNA with high affinity in vitro; thus, the colocalization with gurken mRNA in vivo is likely to be the result of direct binding. Imp mutants support apparently normal regulation of gurken and oskar mRNAs. However, loss of Imp activity partially suppresses a gurken misexpression phenotype, indicating that Imp does act in control of gurken expression but has a largely redundant role that is only revealed when normal gurken expression is perturbed. Overexpression of Imp disrupts localization of gurken mRNA as well as localization and translational regulation of oskar mRNA. The opposing effects of reduced and elevated Imp activity on gurken mRNA expression indicate a role in gurken mRNA regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.