ArticleMolecular and cellular biology2006
HSP70 induction by ING proteins sensitizes cells to tumor necrosis factor alpha receptor-mediated apoptosis.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 62 citations in OpenAlex.
- Heat shock proteins related signature characterizes immune status and predicts prognosis of gliomas.Scientific reports · 2025Article
- Exosomes derived from human amniotic mesenchymal stem cells promotes angiogenesis in hUVECs by delivering novel miRNA N-194.Molecular medicine (Cambridge, Mass.) · 2025Article
- Biological Functions of the ING Proteins.Cancers · 2019Review
- ING2, a tumor associated gene, enhances PAI‑1 and HSPA1A expression with HDAC1 and mSin3A through the PHD domain and C‑terminal.Molecular medicine reports · 2017Article
- Targeting Hsp70: A possible therapy for cancer.Cancer letters · 2016Review
- Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro.Chinese medicine · 2016Article
- LincRNA-p21 acts as a mediator of ING1b-induced apoptosis.Cell death & disease · 2015Article
- Defining the minimal peptide sequence of the ING1b tumour suppressor capable of efficiently inducing apoptosis.Cell death discovery · 2015Article
- Common somatic alterations identified in maffucci syndrome by molecular karyotyping.Molecular syndromology · 2014Article
- SUMOylation of the ING1b tumor suppressor regulates gene transcription.Carcinogenesis · 2014Article
- Reduced ING1 levels in breast cancer promotes metastasis.Oncotarget · 2014Article
- ING1 and ING2: multifaceted tumor suppressor genes.Cellular and molecular life sciences : CMLS · 2013Review
- ING1 induces apoptosis through direct effects at the mitochondria.Cell death & disease · 2013Article
- ING1b-inducible microRNA203 inhibits cell proliferation.British journal of cancer · 2013Article
- Src regulates the activity of the ING1 tumor suppressor.PloS one · 2013Article
- Comparison of classification algorithms with wrapper-based feature selection for predicting osteoporosis outcome based on genetic factors in a taiwanese women population.International journal of endocrinology · 2013Article
- The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway.PLoS biology · 2013Article
- Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis.Cell death & disease · 2012Article
- Inducible hsp70 in the regulation of cancer cell survival: analysis of chaperone induction, expression and activity.Cancers · 2011Article
- Increased stability of Bcl-2 in HSP70-mediated protection against apoptosis induced by oxidative stress.Cell stress & chaperones · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ING proteins affect apoptosis, growth, and DNA repair by transducing stress signals such as DNA damage, binding histones, and subsequently regulating chromatin structure and p53 activity. p53 target genes, including the p21 cyclin-dependent kinase inhibitor and Bax, an inducer of apoptosis, are regulated by ING proteins. To identify additional targets downstream of p33ING1 and p32ING2, cDNA microarrays were performed on phenotypically normal human primary fibroblasts. The 0.36% of genes affected by ING proteins in primary fibroblasts were distinct from targets seen in established cells and included the HSP70 heat shock gene, whose promoter was specifically induced >10-fold. ING1-induced expression of HSP70 shifted cells from survival to a death pathway in response to tumor necrosis factor alpha (TNF-alpha), and p33ING1b protein showed synergy with TNF-alpha in inducing apoptosis, which correlated with reduced NF-kappaB-dependent transcription. These findings are consistent with previous reports that HSP70 promotes TNF-alpha-mediated apoptosis by binding I-kappaBeta kinase gamma and impairing NF-kappaB survival signaling. Induction of HSP70 required the amino terminus of ING1b but not the plant homeodomain region that was recently identified as a histone binding domain. Regulation of HSP70 gene expression by the ING tumor suppressors provides a novel link between the INGs and the stress-regulated NF-kappaB survival pathway important in hypoxia and angiogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.