ArticleInfection and immunity2007
Long-term staphylococcal enterotoxin C1 exposure induces soluble factor-mediated immunosuppression by bovine CD4+ and CD8+ T cells.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 69 citations in OpenAlex.
- Isolation, Antibiogram and Factors Associated With Staphylococcus aureus From Fish at the Landing Site and Selected Restaurants in Central Gondar, Ethiopia: One Health Approach.Veterinary medicine and science · 2026Article
- Effects of injectable trace minerals (Se, Zn, Cu, and Mn) administration on the immune response elicited by primary intranasal modified-live virus vaccination in dairy calves.Veterinary research communications · 2025Article
- Progress towards the Elusive Mastitis Vaccines.Vaccines · 2022Review
- Heterogeneity in FoxP3- and GARP/LAP-Expressing T Regulatory Cells in an HLA Class II Transgenic Murine Model of Necrotizing Soft Tissue Infections by Group A Streptococcus.Infection and immunity · 2018Article
- Bovine Staphylococcus aureus Superantigens Stimulate the Entire T Cell Repertoire of Cattle.Infection and immunity · 2018Article
- Induction of Immunosuppressive CD8Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Genetic engineering of a temperate phage-based delivery system for CRISPR/Cas9 antimicrobials against Staphylococcus aureus.Scientific reports · 2017Article
- Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.Comparative immunology, microbiology and infectious diseases · 2014Article
- Bovine γδ T cells are a major regulatory T cell subset.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine.Journal of immunological methods · 2014Review
- Enterotoxigenic potential of coagulase-negative staphylococci.International journal of food microbiology · 2013Review
- Effect of lipoarabinomannan from Mycobacterium avium subsp avium in Freund's incomplete adjuvant on the immune response of cattle.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
- Targeting mucosal immunity in the battle to develop a mastitis vaccine.Journal of mammary gland biology and neoplasia · 2011Review
- Article
- Detection of classical and newly described staphylococcal superantigen genes in coagulase-negative staphylococci isolated from bovine intramammary infections.Veterinary microbiology · 2011Article
- A quantitative real time PCR method to analyze T cell receptor Vbeta subgroup expansion by staphylococcal superantigens.Journal of translational medicine · 2010Article
- Superantigen-mediated differentiation of bovine monocytes into dendritic cells.Journal of leukocyte biology · 2009Article
- Development of monoclonal antibodies to detect bovine FOXP3 in PBMCs exposed to a staphylococcal superantigen.Veterinary immunology and immunopathology · 2009Article
- Epithelial Cell Gene Expression Induced by Intracellular Staphylococcus aureus.International journal of microbiology · 2009Article
- Enhanced protection against bovine tuberculosis after coadministration of Mycobacterium bovis BCG with a Mycobacterial protein vaccine-adjuvant combination but not after coadministration of adjuvant alone.Clinical and vaccine immunology : CVI · 2008Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Regulatory T cells (T(regs)) help control the development and maintenance of protective immunity and can lead to aberrant immune responses to some pathogens. Several lines of evidence suggest that T(regs) are induced by exposure to superantigens (SAgs) in vitro or in vivo. In this study, bovine peripheral blood mononuclear cells (PBMC) were exposed in vitro to a relatively low dose (5 ng/ml) of staphylococcal enterotoxin C1 (SEC1) for up to 10 days. Upon stimulation, CD4+ and CD8+ T cells initially proliferated at similar rates. Subsequently, from days 6 through 10, most CD4+ and CD8+ T cells proliferated regardless of Vbeta specificity, but the proliferation of CD8+ T cells occurred more vigorously. The transcription of CD25 and CD152 genes increased, whereas that of interleukin-2 (IL-2) decreased. gammadelta T cells appeared to be unresponsive. An increase in the transcription of IL-10 and transforming growth factor beta (TGF-beta) genes in SEC1-stimulated cultures was attributed to the CD4+ CD25+ T-cell subpopulation. The expression of Foxp3 mRNA also increased and was accompanied by the upregulation of CD152 and the downregulation of IL-2 transcription, suggesting that cells in this subpopulation are T(regs). Functionally, SEC1-stimulated CD4+ T cells suppressed the proliferation of naive PBMC in response to heat-killed-fixed Staphylococcus aureus. The suppression was partially mediated by IL-10 and TGF-beta, another characteristic of certain types of T(regs.) The CD8+ T-cell population also suppressed naive PBMC through another mechanism not mediated by IL-10 or TGF-beta. These results provide further insight into the potential mechanisms by which SAgs could contribute to evasion of the immune response, affecting the outcome of infection or colonization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.