ArticlePLoS genetics2006
Heat-shock promoters: targets for evolution by P transposable elements in Drosophila.
Article in PLoS genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 58 citations in OpenAlex.
- A Matter of Degrees: Latitudinal Variation in the Transcriptional Response to High and Low Temperatures in an Estuarine Cnidarian.bioRxiv : the preprint server for biology · 2026Article
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- Impact of Heat Stress on Transposable Element Expression and Derived Small RNAs in Drosophila subobscura.Genome biology and evolution · 2023Article
- The genomic distribution of transposable elements is driven by spatially variable purifying selection.Nucleic acids research · 2023Article
- Experimentally heat-induced transposition increases drought tolerance in Arabidopsis thaliana.The New phytologist · 2022Article
- A population-level invasion by transposable elements triggers genome expansion in a fungal pathogen.eLife · 2021Article
- A unique cluster ofMobile DNA · 2019Article
- Identification of target genes regulated by the Drosophila histone methyltransferase Eggless reveals a role of Decapentaplegic in apoptotic signaling.Scientific reports · 2018Article
- Profuse evolutionary diversification and speciation on volcanic islands: transposon instability and amplification bursts explain the genetic paradox.Biology direct · 2016Article
- Multiple Independent Retroelement Insertions in the Promoter of a Stress Response Gene Have Variable Molecular and Functional Effects in Drosophila.PLoS genetics · 2016Article
- The environmental genomics of metazoan thermal adaptation.Heredity · 2015Review
- Divergence of Drosophila melanogaster repeatomes in response to a sharp microclimate contrast in Evolution Canyon, Israel.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Constant diurnal temperature regime alters the impact of simulated climate warming on a tropical pseudoscorpion.Scientific reports · 2014Article
- Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer.PloS one · 2014Article
- Diversity in the origins of proteostasis networks--a driver for protein function in evolution.Nature reviews. Molecular cell biology · 2013Review
- Hsp90 is important for fecundity, longevity, and buffering of cryptic deleterious variation in wild fly populations.BMC evolutionary biology · 2012Article
- Transcripts from the Drosophila heat-shock gene hsr-omega influence rates of protein synthesis but hardly affect resistance to heat knockdown.Molecular genetics and genomics : MGG · 2011Article
- Evolution of hsp70 gene expression: a role for changes in AT-richness within promoters.PloS one · 2011Article
- Contrasting patterns of transposable element insertions in Drosophila heat-shock promoters.PloS one · 2009Article
- Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transposable elements are potent agents of genomic change during evolution, but require access to chromatin for insertion-and not all genes provide equivalent access. To test whether the regulatory features of heat-shock genes render their proximal promoters especially susceptible to the insertion of transposable elements in nature, we conducted an unbiased screen of the proximal promoters of 18 heat-shock genes in 48 natural populations of Drosophila. More than 200 distinctive transposable elements had inserted into these promoters; greater than 96% are P elements. By contrast, few or no P element insertions segregate in natural populations in a "negative control" set of proximal promoters lacking the distinctive regulatory features of heat-shock genes. P element transpositions into these same genes during laboratory mutagenesis recapitulate these findings. The natural P element insertions cluster in specific sites in the promoters, with up to eight populations exhibiting P element insertions at the same position; laboratory insertions are into similar sites. By contrast, a "positive control" set of promoters resembling heat-shock promoters in regulatory features harbors few P element insertions in nature, but many insertions after experimental transposition in the laboratory. We conclude that the distinctive regulatory features that typify heat-shock genes (in Drosophila) are especially prone to mutagenesis via P elements in nature. Thus in nature, P elements create significant and distinctive variation in heat-shock genes, upon which evolutionary processes may act.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.